中国医学科学院药物研究所-九游官网下载

1. 工作经历
2015.3-至今 中国医学科学院北京协和医学院药物研究所，课题组长
2014.1-2015.2 helmholtz centre for infection research（德国亥姆霍兹感染中心） 化学生物学实验室 junior pi
2010.9-2013.12 sanofi（赛诺菲制药集团）visiting scientist
european molecular biology laboratory博士后
pi: dr. oliver plettenburg (sanofi)
dr. carsten schultz (embl)
2009.7-2010.7 日本名古屋大学 分子设计与有机材料实验室 博士后
导师: prof. eiji yashima（八岛荣次 教授）
2004.9-2009.6 中国科学院化学研究所 分子识别与功能院重点实验室 博士研究生
导师: 陈传峰 (研究员)
2. 教育背景
2004.9-2009.6 中国科学院化学研究所 有机化学专业 博士
2000.9-2004.7 北京理工大学 环境工程专业 学士

化学生物学
以化学生物学为基础，运用化学方法和技术手段，探索生物体内的分子事件，从分子水平认识生命现象的本质，探讨疾病机制。以新药研发为主线，主要针对肿瘤、传染性疾病以及关节炎等重大疾病，开展新型疾病诊断试剂及治疗药物研发，为人类健康提供服务。具体研究内容包括：
1. 酶激活型智能分子探针的设计、合成及应用研究
2. 多模式成像研究
3. 以小分子为运载平台，药物靶向传输研究

1. an activatable lanthanide luminescent probe for time-gated detection of nitroreductase in live bacteria, benjamin brennecke, qinghua wang, qingyang zhang, hai-yu hu*, and marc nazare*, angewandte chemie international edition, 2020.
2. a pseudopaline fluorescent probe for the selective detection of pseudomonas aeruginosa, tianhu zhao†, jian zhang†, xiaowan han†, jun yang, xin wang, maarten vercruysse, hai-yu hu*, xiaoguang lei*, ccs chemistry, 2020.
3. rapid differentiation between bacterial infections and cancer using a near-infrared fluorogenic probe, ling-ling wu, qinghua wang, yali wang, na zhang, qingyang zhang, hai-yu hu*, chemical science, 2020.
4. dual-mode detection of bacterial 16s ribosomal rna in tissues, shengnan xu†, qingyang zhang†, xiaowan han, yali wang, xiang wang, marc nazare, jian-dong jiang*, and hai-yu hu*, acs sensors, 2020.
5. a single component self-assembled thermally activated delayed fluorescence nanoprobe, rao wei†, leilei zhang†, shengnan xu, qingyang zhang, yongxiu qi*, hai-yu hu*, chemical communications, 2020.
6. rationally designed organelle-specific thermally activated delayed fluorescence small molecule organic probes for time-resolved biological applications, qingyang zhang†, shengnan xu†, meng li†, yali wang, na zhang, yan guan, mingxing chen, chuan-feng chen*, hai-yu hu*, chemical communications, 2019.
7. rapid synthesis of γ-halide/pseudohalide-substituted cyanine sensors with programmed generation of singlet oxygen, qingyang zhang†, shengnan xu†, fangfang lai†, yali wang, na zhang, marc nazare, hai-yu hu*, organic letters, 2019.
8. ratiometric fluorescent probes for selective and sensitive visualization of bacterial microenvironment protease activity, qinghua wang†, xiang wang, ying sun, xiaoxiao yang, leilei zhang, qingyang zhang, zhi-qiang hu, hai-yu hu*, chemical communications, 2019.
9. tetrahydro[5]helicene-based fluorescent probe for rapid and sensitive detection of bisulfite in living cells, kun-peng wang, yang lei, ying sun, qingyang zhang, shaojin chen, qi zhang, hai-yu hu⁎, , zhi-qiang hu⁎, sensors and actuators b: chemical, 2018
10. gadolinium-labeled aminoglycoside and its potential application as a bacteria-targeting magnetic resonance imaging contrast agent, leilei zhang†, yun liu†, qingyang zhang, tiegang li, min yang, qingqiang yao, xilei xie, hai-yu hu*, analytical chemistry, 2018.
11. a novel nitroreductase-enhanced mri contrast agent and its potential application in bacterial imaging, yun liu, leilei zhang*, marc nazare, qingqiang yao*, hai-yu hu*, acta pharmaceutica sinica b, 2018.
12. real time detection of eskape pathogens by a nitroreductase-triggered fluorescence turn-on probe, shengnan xu, qinghua wang, qingyang zhang, leilei zhang, limin zuo, jian-dong jiang, hai-yu hu*, chemical communications, 2017.
13. superior fluorogen-activating protein probes based on 3 indole−malachite green, qingyang zhang†, qinghua wang†, ying sun, limin zuo, verena fetz, hai-yu hu*, organic letters, 2017.
14. aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications, qingyang zhang†, qinghua wang†, shengnan xu, limin zuo, xuefu you, hai-yu hu*, chemical communications, 2017.

1. 一种特异性靶向细胞内脂滴的长荧光寿命纳米探针，中国医学科学院药物研究所，2021-03-15
2. 超敏感荧光探针检验细菌中硝基还原酶及在细菌感染应用，中国医学科学院药物研究所，2019-10-23
3. 一种热激活延迟荧光探针分子、其制备及其在细胞成像中的应用，中国医学科学院药物研究所，2019-3-04
4. 热激活延迟荧光( tadf )纳米探针及其制备方法和在生物成像中的应用，哈尔滨医科大学，2018-11-08

1. 2018年，法国梅里埃医学院-中国医学科学院青年科学家奖
2. 2016年，北京市科技新星