中国医学科学院药物研究所-九游官网下载

马双刚，博士，研究员，博士生导师。1999年本科毕业于沈阳药科大学，2004年获沈阳药科大学药物化学专业硕士学位，2008年获北京协和医学院药物化学专业博士学位。同年8月至今在药物研究所天然药物化学研究室工作。
先后承担教育部新教师基金课题、医科院药物所基本科研基金—科研重点与团队建设专项，国家自然基金面上项目、国家重点研发课题等科研项目。在signal transduct. target. ther., chem. sci., org. lett., j. org. chem., j. nat. prod., bioorg. chem., phytochemistry等国际期刊上发表sci论文70余篇；获得中国授权专利14项，其中2项专利获得美国、欧盟、日本等国授权； 获得国家、省部级奖励5项，其中国家科技进步二等奖1项 (2014-j-234-2-01-r09）、北京市科技进步奖一等奖2项（2020-j08-1-01-r06，2013中-1-001-09）、教育部自然科学一等奖1项（2010-38）。参编专著2部。

主要研究方向为天然药物化学：
1. 天然药物活性物质的发现与化学研究
2. 复杂结构活性天然产物的合成与结构简化
3. 基于中药和天然药物有效部位的创新药物研究与开发

1. seco-sesquiterpenes and acorane-type sesquiterpenes with antiviral activity from the twigs and leaves of illicium henryi diels. jin-yao yong#, mi li#, wen-rui li#, rong-mei gao, guo-zhu su, hai-qiang wang, jia yang, li li, yu-huan li, peter scott, ru-bing wang*, xiao-jing wang*, shuang-gang ma*. bioorg. chem. 2023, 131, 106324.
2. bergamotane-type sesquiterpenes from the leaves and twigs of illicium oligandrum and their anti-inflammatory activities, wen-rui li#, jia-ying zhao#, mi li, xiao-jing wang, guo-zhu su, hai-qiang wang, guan-hua du, li li*, ru-bing wang*, shuang-gang ma*, phytochemistry, 2023, 209, 113617.
3. a heme-activatable probe and its application in the high-throughput screening of plasmodium falciparum ring-stage inhibitors. sheng liu#, chunyan wei#, tian liu#, shuang-gang ma#, chen chen, hao lin, lianhui zhang, heng wang*, chong-jing zhang*, shi-shan yu*. signal transduct. target. ther. 2022, 7, 160.
4. antiviral spirooliganones c and d with unique spiro[bicyclo[2.2.2]octane-2,2'-bicyclo[3.1.0]hexane] carbon skeletons from the roots of illicium oligandrum. shuang-gang ma#,*, ru-bing wang#, rong-mei gao, xiao-jing wang, yun-bao liu, yong li, li li, yu-huan li, jing qu*, shi-shan yu*. chin. chem. lett. 2022, 33, 4248-4252.
5. monoterpenoid indole alkaloids isolated from the stems and twigs of strychnos cathayensis. qi-ming pan, yu-huan li, jian-jun zhang, yong li, shuang-gang ma*, shi-shan yu*, phytochemistry, 2022, 203, 113353.
6. library construction of stereochemically diverse isomers of spirooliganin: their total synthesis and antiviral activity. ru-bing wang#, shuang-gang ma#,*, cooper s. jamieson#, rong-mei gao, yun-bao liu, yong li, xiao-jing wang, yu-huan li, kendall n. houk*, jing qu*, shi-shan yu*. chem. sci. 2021, 12: 7003-7011.
7. illihenin a, an antiviral sesquiterpenoid with a cage-like tricyclo[6.2.2.01,5]dodecane skeleton from illicium henryi. jin-yao yong#, wen-rui li#, xiao-jing wang, guo-zhu su, mi li, jian-pei zhang, hong-li jia, yu-huan li, ru-bing wang,* maoluo gan,* and shuang-gang ma*. j. org. chem. 2021, 86, 2, 2017-2022.
8. bioactive prenylated c6-c3 derivatives from the stems and leaves of illicium fargesii. guo-zhu su, ru-bing wang, yong li, li li, yun-bao liu, jing qu, yu-huan li, dan zhang, de-quan yu, shuang-gang ma*, shi-shan yu*. bioorg. chem. 2021, 110, 104734.
9. highly oxidized sesquiterpenes from the fruits of illicium lanceolatum. yang-lan liu#, wen-rui li#, xiao-jing wang, ru-bing wang, mi li, jian-pei zhang, jing-yao yong, xiu-qi bao, dan zhang, shuang-gang ma*. phytochemistry 2020, 172, 112281.
10. new hexalactone derivatives and a pair of new oxaspiro-carbon epimeric glycosides from the fruits of illicium lanceolatum. yang-lan liu#, xiao-jing wang#, ru-bing wang, mi li, wen-rui li, jian-pei zhang, xiu-qi bao, dan zhang, shuang-gang ma*. bioorg. chem. 2019, 91, 103113.
11. new c-2 diastereomers of flavanone glycosides conjugated with 3-hydroxy3-methylglutaric acid from the pericarp of citrus grandis (l.) osbeck. shuang-gang ma#, ru-bing wang#, wen-rui li, yun-bao liu, jing qu, yong li, xiao-jing wang, song xu, shi-shan yu*. bioorg. chem. 2018, 50, 519-524.
12. 3-hydroxy-3-methylglutaryl flavone glycosides from the leaves of turpinia arguta. shuang-gang ma, shao-peng yuan, yun-bao liu, jing qu, yong li, xiao-jing wang, ru-bing wang, song xu, qi hou, shi-shan yu*. fitoterapia 2018, 124, 80-85.
13. illisimonin a, a caged sesquiterpenoid with a new tricyclo[5.2.1.01,6]decane skeleton from the fruits of illicium simonsii. shuang-gang ma#, mi li#, min-bao lin, li li, yun-bao liu, jing qu*, yong li, xiao-jing wang, ru-bing wang, song xu, qi hou, and shi-shan yu*. org. lett. 2017, 19, 6160−6163.
14. bioactive sesquiterpenoids from the roots of artabotrys hexapetalus. feng-min xi, yun-bao liu, jing qu, yong li, zhong-hai tang, li li, yu-huan li, xiao-guang chen, shuang-gang ma*, and shi-shan yu*. tetrahedron 2017, 73, 571-582.
15. antiviral spirotriscoumarins a and b: two pairs of oligomeric coumarin enantiomers with a spirodienone−sesquiterpene skeleton from toddalia asiatica. zhong-hai tang#, yun-bao liu#, shuang-gang ma#, li li, yong li, jian-dong jiang, jing qu*, and shi-shan yu*. org. lett. 2016, 18, 5146-5149.
16. antiviral mono- and bis-prenylated c6-c3 derivatives from the roots of illicium oligandrum. shuang-gang ma, ya gao, hui-qiang wang, yun-bao liu, jing qu, yong li, li li, song xu, hai-ning lv, yu-huan li, and shi-shan yu*. tetrahedron 2016, 72, 3003-3013.
17. artaboterpenoids a and b, bisabolene-derived sesquiterpenoids from artabotrys hexapetalus. feng-min xi, shuang-gang ma, yun-bao liu, li li, and shi-shan yu*. org. lett. 2016, 18 (14), 3374–3377.
18. total syntheses of (−)-spirooliganones a and b and their diastereoisomers: absolute stereochemistry and inhibitory activity against coxsackie virus b3. nan zhao, xiao-dong ren, jin-hong ren, hai-ning lü, shuang-gang ma, rong-mei gao, yu-huan li, song xu, li li, and shi-shan yu*. org. lett. 2015, 17 (12), 3118–3121.
19. total synthesis of illicidione a and illihendione a. xiao-dong ren, nan zhao, song xu, hai-ning lü, shuang-gang ma, yun-bao liu, yong li, jing qu, shi-shan yu. tetrahedron 2015, 71 (29), 4821-4829.
20. diketopiperazines and sesquilignans from the branches and leaves of claoxylon polot. hong-shun gu, shuang-gang ma*, jing qu, yun-bao liu, and shi-shan yu*. planta med. 2015, 81, 748-753.
21. sesquiterpenes from the roots of illicium oligandrum. hai-ning lv, shuang-gang ma*, yun-bao liu, jing qu, yong li, song xu, hua zhu*, shi-shan yu*. j. asian nat. prod. res. 2015, 17(5): 430-438.
22. antiviral spirooliganones a and b with unprecedented skeletons from the roots of illicium oligandrum. shuang-gang ma, rong-mei gao, yu-huan li, jian-dong jiang, ning-bo gong, li li, yang lü, wen-zhao tang, yun-bao liu, jing qu, hai-ning lü, yong li, and shi-shan yu*. org. lett. 2013, 15(17), 4450-4453.
23. prenylated c6-c3 compounds with molecular diversity from the roots of illicium oligandrum. shuang-gang ma, wen-zhao tang, yu-xi liu, you-cai hu, shi-shan yu*, yi zhang, xiao-guang chen, jing qu, jin-hong ren, yun-bao liu, song xu, jing liu, yuan-yan liu, yong li, hai-ning lü, and xian-fu wu. phytochemistry 2011, 72(1), 115-125.
24. four new phenolic diglycosides from the roots of illicium oligandrum. shuang-gang ma#, wen-zhao tang#, shi-shan yu*, xiao-guang chen, yang liu, wen-jie wang, jing qu, song xu, jin-hong ren, yong li, and hai-ning lü. carbohydr. res. 2011, 346(9), 1165-1168.
25. dimeric prenylated c6-c3 compounds from the stem bark of illicium oligandrum. wen-zhao tang#, shuang-gang ma#, jing qu, shi-shan yu*, yun-bao liu, dong-min su, and jing liu. j. nat. prod. 2011, 74(5), 1268-1271.
26. cytotoxic triterpenoid saponins acylated with monoterpenic acid from pithecellobium lucidum. shuang-gang ma, you-cai hu, shi-shan yu*, yi zhang, xiao-guang chen, jing liu, and yu-xi liu. j. nat. prod. 2008, 71(1), 41-46.
*corresponding author; #equal contribution

1. 《三萜化学》，庾石山主编，化学工业出版社，2008年10月。
2. 《高速发展的中国化学:1982—2012》，《高速发展的中国化学》编委会，科学出版社，2012年4月

1. 2014年，中草药微量活性物质识别与获取的关键技术及应用；庾石山，石建功，张东明，于德泉，陈晓光，张建军，王珂，申竹芳，马双刚，屈晶；国家科学技术进步奖，二等奖
2. 2020年，有毒中药活性成分研究与质量安全标准制定及应用；庾石山、张东明、张聿梅、陈晓光、李勇、马双刚、刘云宝、屈晶、侯琦、张丹；北京市科学技术奖，一等奖
3. 2013年，若干重要中草药中微量活性物质的研究；庾石山，石建功，张东明，于德泉，陈晓光，张建军，王珂，申竹芳，马双刚，林生，徐嵩，李勇，屈晶，吕海宁，李创军；北京市科学技术奖，一等奖
4. 2010年，中国若干有毒药用植物活性成分研究；庾石山，陈晓光，再帕尔·阿不力孜，王晓良，屈晶，马双刚，郜嵩，唐美军，刘悦，胡友财，苏东敏；教育部高等学校科技成果奖自然科学奖，一等奖