中国医学科学院药物研究所-九游官网下载

汪小涧，博士，研究员，博士生导师。2010年毕业于中国药科大学药物化学专业，获博士学位。同年进入中国医学科学院药物研究所合成药物化学研究室开展药物化学、新药研发、有机合成方法学等方面的研究工作。2011-2012期间赴美国伊利诺伊州立大学芝加哥分校开展联合研究工作，2011年获得了第14届中国药学会施维雅青年药物化学奖，2014，2016年度获得药物所 “梁周黄于刘”青年科技二等奖，2015年度获得江苏省科学技术一等奖，2016年度获得“协和新星”称号，2018年获得“中国医学科学院青年医学人才”称号。主持承担了多项国家自然科学基金面上基金项目，青年基金项目。以通讯及第一作者共发表sci论文50余篇，申请专利12项，已授权8项。参与新药项目并开展临床研究3项。兼任《中国医药生物技术》编委，《中国药物化学杂志》青年编委。

本课题组针对恶性肿瘤和自身免疫性疾病药物的研发趋势和临床的重大需求，围绕药物化学研究的三个关键科学问题，即分子设计发现，成药性为导向的结构修饰以及创新性方法的交叉应用开展研究工作。重点开展基于受体与配体的药物分子设计，合成，生物活性测试以及成药性评价为核心的药物分子发现研究。
研究方向：
（1）基于人工智能（ai）的药物分子发现研究；
（2）基于受体和配体的药物分子发现研究；
（3）蛋白质翻译后修饰的双功能分子的设计、合成和活性评价。

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1. 世界上市新药2 副主编 化学工业出版社 2010

1. 含二苯基噁二唑的羧酸类化合物、其制备方法及医药用途、汪小涧，刘天琪，金晶，扈金萍，陈晓光，尹大力、zl201711434127.4
2. 含苄氧基苯基的酚类化合物、其制备方法及用途、汪小涧，孙晨斌，葛军，席眉扬，肖琼，尹大力、zl201610922561.6
3. 含五元芳杂环的氨基丙二醇类化合物、其制备方法及其医药用途、田育林，汪小涧，金晶，齐建国，周琬琪，陈晓光，尹大力、zl201410053130.1
4. 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途、齐建国，汪小涧，金晶，田育林，周琬琪，陈晓光，尹大力、zl201410053128.4
5. 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途、韩伟娟，张海婧，汪小涧，金晶，李刚，张翼，肖琼，周婉琪，陈晓光，尹大力、zl201280032727.7

1. 2011、中国药学会施维雅青年药物化学奖、汪小涧、个人奖
2. 2015、江苏省科学技术奖、汪小涧、一等