中国医学科学院药物研究所-九游官网下载

崔华清，中国医学科学院药物研究所研究员，2010年获得德国海德堡大学药物化学博士。研究经历还包括美国明尼苏达大学药物设计中心博士后；英国邓迪大学生物化学与药物研发中心博士交流生、西班牙国家研究机构生物医学与寄生虫病研究所博士交流生。2013年6月加入中国医学科学院药物研究所合成药物化学研究室工作。

1，经典药物化学：基于先导化合物，设计与合成小分子干扰剂，进行药物靶点活性的评价。活性好的化合物继续进行成药性评价，获取临床候选化合物。
2，靶点活性筛选：选取药物蛋白靶标，获取重组蛋白，设计合成底物探针，建立高效、准确的分子水平筛选方法，尤其擅长建立荧光检测方法。
3，体外诊断试剂研发：通过化学与生物学科的交叉方法，专注于研发创新类体外诊断试剂。如，荧光分子探针、核苷类分子探针及其他生化试剂在ivd中的应用。

1, yikun chen, yongxin gao, yujun he, gang zhang, hui wen, yuchen wang*, qinpei wu*, huaqing cui*. determining essential requirements for fluorophore selection in various fluorescent applications taking advantage of diverse structure fluorescence information of chromone derivatives. j. med. chem., 2021; 64(2):1001-1017.
2, yanzhao xu, na qi, hui wen, gang zhang, yuchen wang*, huaqing cui*. synthesis and evaluation of benzenesulfonic acid derivatives as human neutrophil elastase (hne) inhibitors. med. chem. res., 2021, 30: 387-398.
3, yuchen wang‡, jianyi han‡, yanzhao xu, yongxin gao, hui wen*, huaqing cui*. taking advantage of the aromatisation of 7-diethylamino-4-methyl-3, 4-dihydrocoumarin to fluorescently sense superoxide anion. chemcomm., 2020, 56 (68): 9827-9829.
4, yujun he, jin wen, qinghua cui, fangfang lai*, dali yin, huaqing cui*. precisely evaluation in vivo target efficacy of anti-tumour agents via an immunofluorescence and edu labelling strategy. front pharmacol., 2018, 9:812.
5, ning yan, yujun he, hui wen, fangfang lai, dali yin, huaqing cui*. a suzuki-miyaura protocol for labelling proliferating cells containing incorporated brdu. analyst, 2018, 143(5), 1224-33.
6, chunxian he, laura preiss, bing wang, lei fu, hui wen, xiang zhang, huaqing cui*, thomas meier*, and dali yin*. fragment based structural simplification of bedaquiline: the discovery of 3-(4-(n, n-dimethylaminomethyl)phenyl)-quinoline derived anti-tubercular lead compounds. chemmedchem., 2017,12 (2):106-119.
7, hui wen, qinghua cui, hui meng, fangfang lai, xiang zhang, xiaoguang chen, huaqing cui*, dali yin*. a high-resolution method to assess cell multinucleation with cytoplasm-localized fluorescent probes. analyst., 2016, 141 (13), 4010-3.
8, jianzhuang miao‡, huaqing cui‡,*, jing jin, fangfang lai, hui wen, xiang zhang, gian filippo ruda, xiaoguang chen, dali yin*. development of 3-alkyl-6-methoxy-7-hydroxychromones (amhcs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging. chemcomm. 2015, 51 (5): 881-5.
9, huaqing cui, zeeshan kamal, teng ai, yanli xu, swati s more, daniel wilson, liqiang chen. discovery of potent and selective sirtuin 2 (sirt2) inhibitors using a fragment-based approach. j. med. chem. 2014, 57:8340-8357;
10, huaqing cui, juana carrero-lérida, ana. silva, jean l whittingham, james a brannigan, luis ruiz-pérez, kevin read, keith s wilson, dolores. gonzález-pacanowska, ian h gilbert. synthesis and evaluation of α-thymidine analogues as novel antimalarials. j. med. chem. 2012, 55 (24): 10948-10957.

1. 色原酮类衍生物和作为荧光染料的用途；崔华清、尹大力、苗建壮、张翔； 2019授权；zl201410394755.4
2. 一类邻位羰基氨基取代衍生物的制备方法和用途；陈晓光、崔华清、文辉等；2019申请；201910263113.3
3. 一类邻位羰基氨基取代衍生物的制备方法和用途；陈晓光、崔华清、文辉等；2020申请；pct/cn2020/080517
4. 一类含亚砜的苯并恶唑衍生物及其制备方法和用途；崔华清、文辉、王雨辰、贾淑密、王婷、齐娜；2021申请；202110328645.8