中国医学科学院药物研究所-九游官网下载

2006-2010 西南大学药学专业，获得学士学位
2010-2011 中科院上海有机化学研究所担任研究助理，从事天然产物全合成研究（李昂）
2012-2013 新加坡国立大学担任研究助理，从事不对称催化研究（赵宇）
2013-2018 新加坡国立大学有机化学专业，获得博士学位，从事不对称催化研究（赵宇）
2018-2022 美国scripps研究所博士后，从事化学酶法合成研究（hans renata）
2022-至今 中国医学科学院药物研究所，准长聘助理教授、研究员、博士生导师

化学酶法合成是合成生物学与合成化学的联合应用，将二者的优势特点整合优化。通过酶法转化、化学催化手段实现药物合成中的关键化学键形成和手性中心构建，简化合成路线，提高合成效率，降低生产成本，并且减少反应产生的废弃物，降低污染，创建绿色精准的新型合成模式，为合成路线创新和新药开发提供理想的九游官网下载的解决方案。
研究方向包括以下三方面：
1. 通过基因挖掘手段寻找新的酶催化剂，对酶进行改造优化，发展新型酶催化反应；
2. 结合酶催化和化学合成策略制备重要化学中间体，推向活性天然产物和药物分子的合成。
3. 新药发现

1) “diastereoselective synthesis of β-branched α-amino acids via biocatalytic dynamic kinetic resolution,” li, f.;# yang, l.-c.;# zhang, j.; chen, j. s.; renata, h.* angew. chem., int. ed. 2021, 60, 17680-17685. (co-first author; featured in synfacts)
2) “stereoselective access to [5.5.0] and [4.4.1] bicyclic compounds through pd-catalysed divergent higher-order cycloadditions,” yang l.-c.;# wang, y.-n.;# liu, r.; luo, y.; ng, x. q.; yang, b.; rong, z.-q.; lan, y.;* shao, z.;* zhao, y.* nat. chem. 2020, 12, 860-868.
3) “pd-titanium relay catalysis enables switch of alkoxide-π-allyl to dienolate reactivity for spiro-heterocycle synthesis," yang, l.-c.; tan, z. y.; rong, z.-q.; liu, r.; wang, y.-n.; zhao, y.* angew. chem. int. ed. 2018, 57, 7860-7864. (featured in synfacts)
4) “pd-catalyzed enantioselective [6 4] cycloaddition of vinyl oxetanes with azadienes to access ten-membered heterocycles,” wang, y.-n.;# yang l.-c.;# rong, z.-q.; liu, t.-l.; liu, r.; zhao, y.* angew. chem., int. ed. 2018, 57, 1596-1600. (co-first author; featured in synfacts)
5) “nine-membered benzofuran-fused heterocycles: enantioselective synthesis by pd-catalysis and rearrangement via transannular bond formation” rong, z.-q.;# yang, l.-c.;# liu, s.; yu, z.; wang, y.-n.; tan, z. y.; huang, r.-z.; lan, y.;* zhao, y.* j. am. chem. soc. 2017, 139, 15304-15307. (co-first author; featured in synfacts)
6) “construction of nine-membered heterocycles through palladium-catalyzed formal [5 4] cycloaddition,” yang, l.-c.;# rong, z.-q.;# wang, y.-n.; tan, z. y.; wang, m.; zhao, y.* angew. chem. int. ed. 2017, 56, 2927-2931. (featured in synfacts; esi highly cited paper)
7) “acid-assisted ru-catalyzed enantioselective amination of 1,2-diols through borrowing hydrogen,” yang, l.-c.; wang, y.-n.; zhang, y.;* zhao, y.* acs catal., 2017, 7, 93-97. (featured in synfacts)
8) “recent progress and developments in chemoenzymatic and biocatalytic dynamic kinetic resolution” yang, l.-c.; deng, h.; renata, h. org. process res. dev. 2022, 26, 1925-1943. (invited review)
9) “ligand coordination/dissociation-induced divergent allylic alkylations using alkynes," huang, y.; ma, c.; liu, s.; yang, l.-c.; lan, y.;* zhao, y.* chem. 2021, 7, 812-826.
10) “divergent synthesis of complex ent-kauranes, ent-atisanes and ent-trachylobanes via a hybrid oxidative approach,” zhang, x.; king-smith, e.; dong, l.-b.; yang, l.-c.; rudolf, j. d.; shen, b.; renata, h.* science, 2020, 369, 799-806.
11) “dynamic kinetic asymmetric amination of alcohols assisted by microwave: stereo-convergent access to tetralin- and indane-derived chiral amines," rong, z.-q.; yu, z.; weng, c.; yang, l.-c.; lu, s.; lan, y.;* zhao, y.* acs catal. 2020, 10, 9464-9475.
12) “practical, highly stereoselective allyl- and crotylsilylation of aldehydes catalyzed by readily available cinchona alkaloid amide," huang, y.; yang, l.; shao, p.; zhao, y.* chem. sci. 2013, 4, 3275-3281.