中国医学科学院药物研究所-九游官网下载

内蒙古鄂尔多斯人。中国医学科学院药物研究所天然药物化学研究室，研究员，博士生导师。现为全国专业标准化技术委员会专家委员；全国标准样品技术委员会天然产物标准样品专业工作组专家委员；中华中医药学会中药化学分会常务委员；国家禁毒委员会非药用类麻醉药品和精神药品专家委员会委员；沈阳药科大学兼职教授；中科院藏药研究重点实验室客座研究员；《药学学报》和《药学研究》杂志编委。

1. 高活性天然产物的合成与结构修饰
采用仿生和化学方法对结构新颖高活性天然产物进行后修饰和全合成，发现药物先导化合物和药物候选化合物；已完成 虎杖中新骨架polyflavanostilbene b 及其类似物的全合成， 丁烯基苯酞及其衍生物等全合成。
2. 常用中药药效物质基础和天然产物结构确证方法学研究
对常用中药进行系统的化学（常量与微量成分）和生物活性研究，完成了红花、虎杖、连翘、川芎、苦参等三十余种中药药效物质基础，发现了1000多个新天然化合物。建立天然产物、尤其是复杂天然产物结构的nmr鉴定体系。
3. 抗缺血性脑卒中活性、肿瘤免疫活性、降糖活性等创新药物研究
完成具有抗缺血性脑卒中活性的红花新苷及其类似物的合成、具有肿瘤免疫活性s6系列先导药物的全合成，及具有降糖活性红景天活性部位初步临床前研究。

1. jichao zhou#, yuanyuan liu#, xiaoli wei#, meng yuan#, xu zhang#, lingfeng qin, bing cui, pingping li, jing zhang, ziming feng, jianshuang jiang, xiang yuan, ruibing xu, zhimeng zhang, peicheng zhang*, xiaowei zhang*, yanan yang*, glycnsisitin a: a promising bicyclic peptide against heart failure that facilitates tfrc-mediated uptake of iron in cardiomyocytes, acta pharmaceutica sinica b, 2024, 14, 3125-3139.
2. gangsheng li, xiang yuan, fu liu, zhihua liu, xujie wang, yuanyuan liu, yanmin chen, tingting wang, yanan yang*, peicheng zhang*, three-step synthesis of flavanostilbenes with a 2-cyclohepten-1-one core by cu-mediated [5   2] cycloaddition/decarboxylation cascade, chinese chemical letters, 2024, doi: https://doi.org/10.1016/j.cclet.2024.109880.
3. linghao zhao; haiwei yan; jianshuang jiang; xu zhang; xiang yuan; yanan yang*; peicheng zhang*; effective assignment of positional isomers in dimeric shikonin and its analogs by 1h nmr spectroscopy. chinese chemical letters, 2024, 35, 108863.
4. xu zhang#, jiang li#, kai-zhou lu#, ya-nan yang, jian-shuang jiang, xiang yuan, zi-ming feng, fei ye*, pei-cheng zhang*, neosophoflavonoids a–c, a class of highly oxidized hybrid flavonoids from sophora flavescens with antidiabetic effects, chinese chemical letters, 2024, 35, 109456.
5. zhenyuan li#, shuying li#, zeyu xing#, quanchang gu, rongrong du, jianshuang jiang, xiang yuan, xu zhang, xiaoguang chen, nina xue, peicheng zhang*, jing jin*, yanan yang*, discovery of natural ah receptor antagonists from salvia miltiorrhiza bunge and synthesis of analogs for tumor immunotherapy, journal of medicinal chemistry, 2024, 67, 1243-1261.
6. rong-rong du#, ji-chao zhou#, wen-jie qin, kai-zhou lu, xiu-mei duan, ya-nan yang, xiang yuan, kun li*, xiao-wei zhang*, pei-cheng zhang*, fourteen new 2-benzylbenzofuran glycosides with cardioprotective activity from heterosmilax yunnanensis, bioorganic chemistry, 2024,143,107079.
7. jun cao#, jiali chen#, rongrong du, qingwen zhang, lishe gan, peicheng zhang*, ligen lin*, garcimultiflins a–c, unusual polycyclic polyprenylated acylphloroglucinols from the pericarps of garcinia multiflora as interleukin-1β and pyroptosis inhibitors, organic chemistry frontiers, 2023, 10, 4311–4319
8. hai-wei yan, rong-rong du, xu zhang, ya-nan yang, xiang yuan, zi-ming feng, jian-shuang jiang, pei-cheng zhang*, chinese chemical letters, 2022, 33, 2555–2558.
9. xiang yuan, jianshuang jiang, yanan yang, xu zhang, ziming feng, peicheng zhang*, three quinolizidine dimers from the seeds of sophora alopecuroides and their hepatoprotective activities, chinese chemical letters, 2022, 33, 2923–2927.
10. hai-wei yan, ya-nan yang, xu zhang, jian-shuang jiang, xiang yuan, zi-ming feng, pei-cheng zhang*, eight new arnebinol b-based meroterpenoids with planar chirality in the constrained 6/10/5 tricyclic skeleton from arnebia euchroma and their cytotoxicities, bioorganic chemistry, 2022, 128, 106091.
11. quan-chang gu#, xiao-li wei#, qing ji#, zi-ming feng, jian-shuang jiang, xu zhang, xiang yuan, xiao-wei zhang*, pei-cheng zhang*, ya-nan yang*, two dimers generated by lithospermic decarboxylation coupling from danshen, bioorganic chemistry, 2022, 128, 106065.
12. xiang yuan, zhenyuan li, ziming feng, jianshuang jiang, yanan yang, peicheng zhang*, alopecuroidines a−c, three matrine-derived alkaloids from the seeds of sophora alopecuroides, chinese chemical letters, 2021, 32, 4058–4062.
13. si-yuan shao, fan zhang, ya-nan yang, zi-meng feng, jian-shuang jiang, pei-cheng zhang*, neuroprotective and anti-inflammatory phenylethanoidglycosides from the fruits of forsythia suspensa, bioorganic chemistry, 2021, 113, 105025.
14. jia zhang, ya-nan yang, jian-shuang jiang, zi-ming feng, xiang yuan, xu zhang, pei-cheng zhang*, new dimeric phloroglucinol derivatives from agrimonia pilosa and their hepatoprotective activities, bioorganic chemistry, 2021, 116, 105341.
15. ya-nan yang, hui zhu, xiang yuan, xu zhang, zi-ming feng, jian-shuang jiang, pei-cheng zhang* seven new prenylated flavanones from the roots of sophora flavescens and their anti-proliferative activities. bioorganic chemistry, 2021, 109, 104716.
16. hai-wei yan, ling-hao zhao, xu zhang, ya-nan yang, xiang yuan, and pei-cheng zhang*, photoinduced irreversible intramolecular proton transfer of arnebinones b, d, and e: the case of photoenolization at the p‑benzoquinone-ch2/ch‑π system, journal of natural products, 2021, 84, 2981−2989.
17. kai-zhou lu, zi-ming feng, xiang yuan, ya-nan yang, jian-shuang jiang, xu zhang*, pei-cheng zhang*, five novel pterocarpan derivatives from sophora flavescens, chinese journal of chemistry, 2021, 39, 2763-2768.
18. chemical constituents of ligusticum chuanxiong and their anti-inflammation and hepatoprotective activities. xiang yuan, bing han, zi-ming feng, jian-shuang jiang, ya-nan yang, and pei-cheng zhang*. bioorganic chemistry, 2020, 101, 104016.
19. 1,2-dibromoethane and ki mediated α-acyloxylation of ketones with carboxylic acids. xu-jie wang, gang-sheng li, ya-nan yang, zi-ming feng, jian-shuang jiang, and pei-cheng zhang*, chinese chemical letters, 2020, 31, 711-714.
20. bioactive butylphthalide derivatives from ligusticum chuanxiong. xu zhang, zi-ming feng, ya-nan yang, jian-shuang jiang, and pei-cheng zhang*. bioorganic chemistry, 2019, 84, 505-510.
21. six new compounds from the flowers of chrysanthemum morifolium and their biological activities. pei-fei yang, ya-nan yang, zi-ming feng, jian-shuang jiang, and pei-cheng zhang*, bioorganic chemistry, 2019, 82, 139-144.
22. stereospecific acyloin ring contraction controlled by glucose and concise total synthesis of saffloneoside. wan gao, jian-shuang jiang, zhong chen, ya-nan yang, zi-ming feng, xu zhang, xiang yuan, and pei-cheng zhang*, organic chemistry frontiers, 2019, 6, 1858−1862.
23. a concise approach for determining the relative configuration of h-7 and h-8 in 8,4′-oxyneolignans by 1h nmr spectroscopy. ya-nan yang, bing han, peng-fei yang, zi-ming feng, jian-shuang jiang, and pei-cheng zhang*, organic chemistry frontiers, 2019, 6, 886−891.
24. iron-catalyzed synthesis of the hexahydrocyclopenta[c]furan core and concise total synthesis of polyflavanostilbene b. xu-jie wang, fu liu, ju-ping yun, zi-ming feng, jian-shuang jiang, ya-nan yang*, and pei-cheng zhang*. angewandte chemie-international edition, 2018, 57, 10127−10131.

1. 《黄酮化学》，主编，化学工业出版社，2008；
2. 《有机波谱解析》，编者，人民卫生出版社，2023；
3. 《新精神活性物质办案实用手册》，编者，法律出版社，2019；
4. 《中国食用药用真菌化学》，编者，上海科学技术文献出版社，2016；
5. 《天然药物化学研究》，编者，中国协和医科大学出版社，2006；
6. 《天然产物化学进展》，编者，化学工业出版社，2005。

1. a环具有异戊烯基的醌式查尔酮化合物，制法与抗炎活性 张培成，侯琦，陈钟，林明宝，杨桠楠，袁绍鹏，冯子明，白金叶，姜建双 zl 2014 1 2020017.8
2. 一类a环具有甲基的醌式查尔酮化合物，制法与抗炎活性 张培成，侯琦，陈钟，林明宝，杨桠楠，袁绍鹏，冯子明，白金叶，姜建双 zl 2014 1 0218831.6
3. 一类来源连翘的化合物，其制法及在防治帕金森病的应用 陈乃宏，张培成，宋修云，张凡，张挽青，杨桠楠，冯子明，姜建双 zl 2014 1 0223754.3
4. 一种连翘活性部位的制备及其在防治帕金森病中的应用张培成，陈乃宏，宋修云，张凡，张挽青，杨桠楠，冯子明，姜建双 zl 2014 1 0223825.x
5. 一类黄烷化合物，其制备方法及降糖活性 张培成，叶菲，杨桠楠，田金英，贠菊萍，张晓琳，冯子明，黄立伟，姜建双，李莫涵，安亚文，唐冉琪 zl 2014 1 0215130.7
6. 一类黄烷化合物在防治神经退行性疾病中的应用 张培成，陈乃宏，贠菊萍，宋修云，杨桠楠，冯子明，姜建双 zl 2014 1 0215128.x
7. 一种红景天有效部位、其制备方法、其药物组合物及用途 张培成，叶菲，杨桠楠，田金英，冯子明，张晓琳，姜建双，陈玲，刘照振，贺伊博，陈钟，韩静，刘俊玚 zl 2010 1 0587820.7
8. 防治胰岛素抵抗及其相关代谢综合征的中药组合物 叶菲，张培成，田金英，杨桠楠，张晓琳，冯子明，陈玲，姜建双，韩静，刘照振，李娟，陈钟，付建阳 zl 2010 1 0587797.1
9. 酞丁安衍生物及其制备方法和用途 潘显道，张培成，杨亚军，赵立敏 zl 2011 1 0131922.2

2016-01-01 中药中具有新颖结构的亲水性活性分子发现与结构解析 二等奖 中国分析测试协会