中国医学科学院药物研究所-九游官网下载

2005年本科毕业于山东大学药学院。2008年硕士毕业于北京协和医学院药物研究所。2013年毕业于新加坡国立大学化学系药物化学专业，获得博士学位。同年获得中国优秀自费留学生奖学金。2017年入选国家级高层次人才项目。2017年4月作为中国医学科学院“高端人才引进计划”首位入选者，到北京协和医学院药物所工作，任课题组长。《药学学报》中英两刊青年编委。

化学生物学和创新药物发现。
（1）利用化学蛋白质组学技术，阐明活性分子的蛋白靶标和作用机制，开展机制指导的先导化合物发现。
（2）设计、合成小分子荧光探针，用于先导化合物的发现。

(1) xu, m.; ma, x.; ye, z.; wang, f.; xu, s.; zhang, c.-j.* “concentration-dependent enrichment identifies primary protein targets of multitarget bioactive molecules”. j. proteome res. 2023, 22, 802−811.
(2) wang, k.#; chen, l.#; dai, x.#; ye, z.; zhou, c.; zhang, c.-j.*; feng, z.* “synthesis and structure-activity relationships of n - (3 - (1h-imidazol-2-yl)phenyl) - 3-phenylpropionamide derivatives as a novel class of covalent inhibitors of p97/vcp atpase.” eur. j. med. chem., 2023, 248, 115094.
(3) chen, k.#; wang, t.#; li, y.#; wu, j.#; zhao, c.-x.; liu, s.; sun, f.; fang, y.; hu, j.; hu, j.; zhang, c.-j.*; yu. h.*; ma, c.*; yu, s.-s.* “rhodojaponin vi indirectly targets cav2.2 channels via n-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain”. acta pharm. sin. b. 2023,13, 1326-1336.
(4) liu, s.#; wei, c.#; liu, t.#; ma, s.-g.#; chen, c.; lin, h.; zhang, l.; wang, h.*; zhang, c.-j.*; yu, s.-s.* “a heme-activatable probe and its application in the high-throughput screening of plasmodium falciparum ring-stage inhibitors”. signal transduct target ther, 2022, 7, 160.
(5) ye, z.#; wang, k.#; chen, l.; jin, x.; chen, h.; tang, g.; yao, s.q.; feng, z.*; zhang, c.-j.* “a targeted covalent inhibitor of p97 with proteome-wide selectivity”. acta pharm. sin. b. 2022,12, 982-989.
(6) chen, l.; wang, h.; ji, t.-f.*; zhang, c.-j.* “chemoproteomics-based target profiling of sinomenine reveals multiple protein regulators of inflammation”. chem. commun., 2021, 57, 5981-5984.
(7) zhao, c.; liu, t.; xu, m.; lin, h.; zhang, c.-j.* “a fundamental study on the fluorescence-quenching effect of nitro groups in tetraphenylethene aie dyes with electron-withdrawing groups”. chin. chem. lett. 2021, 32, 1925-1928.
(8) wei, c.; zhao, c.; liu, s.; zhao, j.; ye, z; wang, h.*; yu, s.*; zhang, c.-j.* “activity-based protein profiling reveals thatsecondary-carbon-centered radicals of synthetic 1,2,4-trioxolanes are predominately responsible for modification of protein targets in malaria parasites”. chem. commun., 2019, 55, 9535.
(9) lin, h.; yang, w.-q; ye, z; zhang, c.-j*. “identification of potent caspase-8 inhibitors from a library of fluorescent natural products screened by an aiegen-based light-up probe.” chembiochem, 2019, 20, 1292 – 1296. (invited paper in the special issue of young chembio talent).
(10) lin, h.; yang, h.; huang, s.; wang, f.; wang, d.-m.; liu, b*.; tang, y.-d*.; zhang, c.-j*., caspase‑1 specific light-up probe with aggregation-induced emission characteristics for inhibitor screening of coumarin-originated natural products. acs appl. mater. interfaces. 2018, 10, 12173−12180.
(11) feng, g.; liu, j.; zhang, c.-j*.; liu, b*. artemisinin and aiegen conjugate for mitochondria-targeted and image-guided chemo- and photodynamic cancer cell ablation. acs appl. mater. interfaces. 2018, 10, 11546−11553.
(12) yang, h.#; wang, f.#; zheng, j.; lin, h.; liu, b*.; tang, y.-d*.; zhang, c.-j*. super-quenched molecular probe based on aggregation-induced emission and photoinduced electron transfer mechanisms for formaldehyde detection in human serum. chem asian j. 2018, 13, 1432-1437.
(13) zhang, c.-j.#; wang, j.#*; zhang, j.; lee, y. m.; feng, g.; lim, t. k.; shen, h.; lin, q.; liu, b*. mechanism-guided design and synthesis of mitochondria-targeting artemisinin analogue with enhanced anticancer activity. angew. chem. int. ed., 2016, 55, 13770-13774.
(14) zhang, c.-j.; feng, g.; xu. s.; zhu, z.; lu. x.; wu. j.; liu, b*. structure-dependent cis/trans isomerization for tetraphenylethenederivatives: consequences for aggregation-induced emission. angew. chem. int. ed., 2016, 55, 6192-6196. (selected as very important paper).
(15) zhang, c.-j.#; hu, q.#; feng, g.; zhang, r.; yuan, y.; liu, b*. image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics. chem. sci., 2015, 6, 4580-4586.
(16) wang, j. *#; zhang, c.-j.#; chia, w. n.; loh, c. c. y.; li, z.; lee, y. q.; lee, y. m.; he, y.; yuan, l.; liu, m.; liew, c. x.; zhang, j.; lim, t. k.; lim, c. k.; shen, h. m.; tan, k. s. w. *; lin, q. s*. haem-activated promiscuous targeting of artemisinin in plasmodium falciparum. nat. commun, 2015, 6, 10111.
(17) zhang, c.-j.; tan, c. y. j.; ge, j.; na, z.; chen, g. y. j.; uttamchandani, m.; sun, h.; yao, s. q*. preparation of small-molecule microarrays by trans-cyclooctene tetrazine ligation and their application in the high-throughput screening of protein–protein interaction inhibitors of bromodomains. angew. chem. int. ed., 2013, 52, 14060-14064. (selected as hot paper).
(18) yuan, y.#; zhang, c.-j.#; kwok, r. t. k.; xu, s.; zhang, r.; wu, j.; tang, b. z.; liu, b*. light-up probe for targeted and activatable photodynamic therapy with real-time in-situ reporting of sensitizer activation and therapeutic responses. adv. funct. mater, 2015, 25, 6586-6595.
(19) yuan, y.#; zhang, c.-j.#; liu, b*. a photoactivatable aie polymer for light-controlled gene delivery: concurrent endo/lysosomal escape and dna unpacking. angew. chem. int. ed., 2015, 54, 11419-11423.
(20) yuan, y.#; zhang, c.-j.#; gao, m.; zhang, r.; tang, b. z.; liu, b*. specific light-up bioprobe with aggregation-induced emission and activatable photoactivity for the targeted and image-guided photodynamic ablation of cancer cells. angew. chem. int. ed., 2015, 54, 1780-1786.
*corresponding author； # equal contribution