中国医学科学院药物研究所-九游官网下载

刘陆平 女，研究员，博士生导师。2022年7月，全职入职中国医学科学院北京协和医学院药物研究所，任课题组长。课题组致力于化学和生物学前沿交叉研究，关注新型生物化学技术研发和新药创制。迄今在 nature chemistry（2篇）、j. am. chem. soc.、angew. chem. 等国际知名刊物上发表论文20余篇，获国际发明专利授权 3 项。荣获thieme chemistry journals award 2023，2022年北京市科技新星计划创新新星，留德华人化学化工学会青年化学奖 (一等奖)，国家优秀自费留学生奖学金等多项荣誉。2006至2013年就读于兰州大学，师从王锐院士，获生物技术学士学位和生物化学与分子生物学硕士学位。2013年8月，前往德国马克斯–普朗克煤炭研究所（max planck institute for coal research）攻读有机化学博士学位，师从benjamin list教授（2021 诺贝尔化学奖得主），进行有机不对称催化合成相关研究。2018年1月加入美国加州大学圣地亚哥分校（ucsd）neal devaraj教授课题组，从事化学生物学的博士后研究。

刘陆平课题组关注基础有机化学和现代生物医药技术的融合，主要研究方向包括：
1. 精准调控生物正交化学技术的研发与应用；
2. 生物相容性催化化学；
3. 生物药物和分子探针。

1. luping liu; dongyang zhang; mai johnson; neal k. devaraj*. light-activated tetrazines enable precision live-cell bioorthogonal chemistry, nature chemistry, 2022, 14: 1078–1085.
2. dongyang zhang; luping liu; shuaijiang jin; ember tota; zijie li; xijun piao; xuan zhang; xiang-dong fu; neal k. devaraj*. site-specific and enzymatic cross-linking of sgrna enables wavelength-selectable photoactivated control of crispr gene editing, journal of the american chemical society, 2022, 144(10): 4487–4495.
3. luping liu; yike zou; ahanjit bhattacharya; dongyang zhang; susan q. lang; k. n. houk; neal k. devaraj*. enzyme-free synthesis of natural phospholipids in water, nature chemistry, 2020, 12: 1029–1034.
4. luping liu; hyejin kim; youwei xie; christophe farés; philip s. j. kaib; richard goddard; benjamin list*. catalytic asymmetric [4 2] cycloaddition of dienes with aldehydes, journal of the american chemical society, 2017, 139(39): 13656–13659.
5. luping liu#; philip s. j. kaib#; aurélientap; benjamin list*. a general catalytic asymmetric prins cyclization, journal of the american chemical society, 2016, 138(34): 10822–10825.
6. sayantani das#; luping liu#; yiying zheng; m. wasim alachraf; walter thiel*; chandra kanta de*; benjamin list*. nitrated confined imidodiphosphates enable a catalytic asymmetric oxa-pictet-spengler reaction, journal of the american chemical society, 2016, 138(30): 9429–9432.
7. luping liu; markus leutzsch; yiying zheng; m. wasim alachraf; walter thiel; benjamin list*. confined acid-catalyzed asymmetric carbonyl-ene cyclization, journal of the american chemical society, 2015, 137(41): 13268–13271.
8. luping liu; dekui zhang; panpan zhang; xianxing jiang*; rui wang*. catalytic highly asymmetric 1,5(6)-selective cyclization reaction of α-hydroxyimino cyclic ketones: direct approach to ring-fused hydroxyimino dihydropyrans, organic and biomolecular chemistry, 2013, 11: 5222–5225.
9. xianxing jiang*; luping liu; panpan zhang; yuan zhong; rui wang*. catalytic asymmetric β,γ activation of α,β-unsaturated γ-butyrolactams: direct approach to β,γ-functionalized dihydropyranopyrrolidin-2-ones, angewandte chemie international edition, 2013, 52(43): 11329–11333.
10. luping liu; yuan zhong; panpan zhang; xianxing jiang*; rui wang*. the core scaffold-inspired stereoselective synthesis of spiropyrazolones via an organocatalytic michael/cyclization sequence, journal of organic chemistry, 2012, 77(22): 10228–10234.

1. light-controlled bioorthogonal tetrazine ligation, neal k. devaraj; luping liu; 2022-4-7, wipo, wo2022/072374 a1.