中国医学科学院药物研究所-九游官网下载

田育林，博士，副研究员，硕士生导师。2010年本科毕业于沈阳药科大学基础药学理科基地班，2015年在北京协和医学院-中国医学科学院药物研究所取得药物化学博士学位，2015-2018年在纽约州立大学水牛城分校从事博士后研究，2018年进入中国医学科学院药物研究所工作，主要从事药物化学与化学生物学研究，近年来在j. am. chem. soc., org. lett., chem. commun., chin. chem. lett.等杂志发表论文30多篇，2020年获得北京市科技新星计划资助，2022年获得药物所“梁周黄于刘青年科技奖”三等奖。

主要从事药物化学与化学生物学研究，具体包括：
1、新型肿瘤光诊疗探针的开发与应用。
2、基于生物正交反应的新型化学生物学工具的开发与应用。
3、基于结构的药物分子设计、合成与生物活性研究。

1. yu teng, rongrong zhang, bingbing yang, hong yang, xiang li, dali yin, xinchi feng*, yulin tian*, bioorthogonally-activated tetraphenylene-tetrazine aggregation-induced emission fluorogenic probes, j. mater. chem. b, 2022, 10(42), 8642–8649. (inside front cover)
2. yongcheng wang‡, yu teng‡, hong yang, xiang li, dali yin, yulintian*, bioorthogonally applicable multicolor fluorogenic naphthalimide–tetrazine probes with aggregation-induced emission characters, chem. commun., 2022, 58 (7), 949-952. (back cover)
3. xiang li‡, hong yang‡, yu teng, yongcheng wang, dali yin, yulin tian*, a general strategy for in situ assembly of light-up fluorophores via bioorthogonal suzuki-miyaura cross-coupling, chin. chem. lett., 2022, 33 (9), 4223-4228.
4. yu teng, hong yang, xiang li,yongcheng wang, dali yin, yulintian*, a bioorthogonal-activated fluorescence turn-on probe based on nitrone-modified 1,8-naphthalimide for live-cell imaging, chin. j. chem., 2022, 40 (2), 209-214. (back cover)
5. yulin tian*, hong yang, xiang li, yongcheng wang, yu teng, dali yin, design of nitroso-modified naphthylene-based fluorophores as photoactivatable bioorthogonal turn-on probes, org. lett., 2021, 23 (9), 3782-3787.
6. yulin tian, ming fang, qing lin*, intracellular bioorthogonal labeling of glucagon receptor via tetrazine ligation, bioorg. med. chem., 2021, 43, 116256.
7. hong yang, yongcheng wang, xiang li, yu teng, yulin tian*, a dansyl amide n-oxide fluorogenic probe based on a bioorthogonal decaging reaction, chemistryopen, 2021, 10 (10), 1013-1019.
8. xiang li, yongcheng wang, hong yang, dali yin, yulin tian*, design of hydrazone-modified 1,8-naphthalimides as fluorogenic click probes based on nitrile imine-alkyne cycloaddition, eur. j. org. chem., 2020, 2020 (28), 4296–4300. (cover feature)
9. yulin tian*‡, xiang li‡, dali yin, development of 4-oxime-1,8-naphthalimide as a bioorthogonal turn-on probe for fluorogenic protein labeling, chem. commun., 2019, 55 (85), 12865-12868.
10. yulin tian, qing lin*, fitness factors for bioorthogonal chemical probes, acs chem. biol., 2019, 14 (12), 2489−2496.
11. yulin tian, huafei zou, peng an, zhihong zhou, weijun shen*, qing lin*, design of stapled oxyntomodulin analogs containing functionalized biphenyl cross-linkers, tetrahedron, 2019, 75 (2), 286-295.
12. yulin tian, qing lin*, recent development of photo-cross-linkers as tools for biomedical research, chimia, 2018, 72 (11), 758-763.
13. yulin tian, qing lin*, genetic encoding of 2-aryl-5-carboxytetrazole-based protein photo-cross-linkers, chem. commun., 2018, 54 (35), 4449-4452.
14. yulin tian, marco paolo jacinto, yu zeng, zhipeng yu, jun qu, wenshe r. liu, qing lin*, genetically encoded 2-aryl-5-carboxytetrazoles for site-selective protein photo-cross-linking, j. am. chem. soc., 2017, 139 (17), 6078–6081.
15. yulin tian, xiaojian wang*, qiong xiao, chenbin sun, dali yin*, synthesis of dihydrobenzoheterocycles through al(otf)3-mediated cascade cyclization and ionic hydrogenation, j. org. chem., 2014, 79, 9678-9685.
16. yulin tian‡, jing jin‡, xiaojian wang*, jinping hu, qiong xiao, wanqi zhou, xiaoguang chen, dali yin*, discovery of oxazole and triazole derivatives as potent and selective s1p1 agonists through pharmacophore-guided design, eur. j med. chem., 2014, 85, 1-15.
17. yulin tian, jianguo qi, chenbin sun, dali yin, xiaojian wang*, qiong xiao, one-pot synthesis of 4-methylisoquinolines via sequential pd-catalyzed heck reaction and intramolecular cyclization, org. biomol. chem., 2013, 11, 7262-7266.
18. yulin tian, jing jin, xiaojian wang, weijuan han, gang li, wanqi zhou, qiong xiao, jianguo qi, xiaoguang chen, dali yin*, design, synthesis and docking-based 3d-qsar study of novel 2-substituted 2-aminopropane-1,3-diols as potent and selective agonists of sphingosine-1-phosphate 1 (s1p1) receptor, medchemcomm, 2013, 4, 1267-1274.
19. 田育林, 金晶, 汪小涧, 选择性鞘胺醇-1-磷酸受体1激动剂研究进展, 药学学报, 2012, 47(1), 7-17.

1. 艾托莫德的制备方法，陈思，石泽玉，肖琼，张翔，田育林，尹大力，中国发明专利，2022-06-21，专利号：zl201811244306.6.
2. 一种艾托莫德的制备方法，陈思，石泽玉，肖琼，张翔，田育林，尹大力，中国发明专利，2022-06-21，专利号：zl201811244290.9.
3. 普赛莫德的制备方法，石泽玉，陈思，肖琼，张翔，田育林，尹大力，中国发明专利，2022-06-21，专利号：zl201811244302.8.
4. 一种普赛莫德的制备方法，石泽玉，陈思，肖琼，张翔，田育林，尹大力，中国发明专利，2022-07-19，专利号：zl201811244291.3.
5. oxyntomodulin analogs and methods of making and using same, qing lin, avinash muppidi, weijun shen, huafei zou, peter schultz, yulin tian, us patent, 2018-04-03, no. us9931379b2.
6. 含五元芳杂环的氨基丙二醇类化合物、其制备方法及其医药用途，田育林，汪小涧，金晶，齐建国，周琬琪，陈晓光，尹大力，中国发明专利，2019-04-09, 专利号：zl201410053130.1.
7. 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途，齐建国，汪小涧，金晶，田育林，周琬琪，陈晓光，尹大力，中国发明专利，2018-10-30, 专利号：zl201410053128.4.

2020年北京市科技新星
2022年中国医学科学院药物研究所“梁周黄于刘青年科技奖”三等奖