中国医学科学院药物研究所-九游官网下载

2012年本科毕业于北京大学药学院，2018年博士毕业于北京大学基础医学院免疫学专业。2018年入职于中国医学科学院药物研究所，2022年获聘为副研究员。入选北京市青年人才托举工程，主持国家自然科学基金青年项目、中央高校基本科研业务费项目。参与国家重点研发计划、国家自然科学基金重点项目、中国医学科学院医学与健康科技创新工程等项目。发表文章20余篇，授权专利9项。

1. 肌萎缩侧索硬化症、阿尔茨海默病的发病机制和新靶点研究。
2. 创伤性脑损伤修复机制及相关药物研究。

(1) jingshu tang, yuying kang, yujun zhou, nianying shang, xinnan li, hongyue wang, jiaqi lan, shuai wang, lei wu, ying peng*; timp2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting src-dependent ve-cadherin internalization. j clin invest. 2023 nov 28:e164199.
(2) jingshu tang#, yuying kang#, yujun zhou, qiuyu chen, jiaqi lan, xuebin liu*, ying peng*; umbilical cord mesenchymal stem cell-conditioned medium inhibits microglial activation to ameliorate neuroinflammation in amyotrophic lateral sclerosis mice and cell models. brain research bulletin, 2023 oct 1:202:110760.
(3) yong zhang#, jingshu tang#, yujun zhou, qiong xiao, qiuyu chen, hongyue wang, jiaqi lan, lei wu, ying peng*; short-term exposure to dimethyl fumarate (dmf) inhibits lps-induced iκbζ expression in macrophages. frontiers in pharmacology, 2023, 14:1114897.
(4) jingshu tang, yuying kang, yujun zhou, xinnan li, jiaqi lan, lei wu, xinhong feng*, ying peng*; als-causing sod1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the itch/eps15/rab5 axis. neurobiology of disease, 2021, 153.
(5) jingshu tang, yuying kang, longjian huang, xinhong feng, lei wu, ying peng*; neuroprotective effects of hemocoagulase agkistrodon on experimental traumatic brain injury. brain research bulletin, 2021, 170: 1-10.
(6) jingshu tang, yuying kang, longjian huang, lei wu, ying peng*; timp1 preserves the blood–brain barrier through interacting with cd63/integrin β1 complex and regulating downstream fak/rho a signaling. acta pharmaceutica sinica b, 2020, 10(6): 987-1003.
(7) jingshu tang#, jingxuan zhang#, yang liu, qinyuan liao, jing huang, zihan geng, weiyan xu, zhengzuo sheng, gregory lee, youhui zhang, jinfeng chen, liang zhang*, xiaoyan qiu*; lung squamous cell carcinoma cells express non-canonically glycosylated igg that activates integrin-fak signaling. 2018 aug 28, 430:148-159.
(8) jingshu tang, bingxue xie, xiling bian, yu xue, ningning wei, jingheng zhou, yuchen hao, gang li, liangren zhang*, kewei wang*; identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, br-iq17b. acta pharmacol sin, 2015 jul, 36(7):800-12.

(1) timp-1在制备预防或治疗创伤性脑损伤药物中的应用. 中国, 授权日: 2023-9-26, 专利号: zl 201910852472.2.
(2) 一种治疗精神分裂中的中药组合物. 中国, 授权日: 2022-5-24, 专利号: zl 201911047800.8.
(3) 一种治疗焦虑并抑郁症的中药组合物. 中国, 授权日: 2022-2-18, 专利号: zl 201911046338.x.
(4) 一种治疗抑郁症的中药组合物. 中国, 授权日: 2022-2-18, 专利号: zl 201911057184.4.
(5) igg抗原表位及其作为靶点的应用. 中国, 授权日: 2022-9-13, 专利号: zl 201810330585.1. 日本, 授权日期: 2022-10-12, 专利号: jp7156647b2.
(6) 一种噻唑并嘧啶酮化合物及其制备方法和应用. 中国, 授权日期: 2020-9-15, 专利号: zl 201510299946.7. 美国, 授权日期: 2019-10-22, 专利号: us10450326b2.
(7) 2-中氮茚甲酰胺类化合物及其制备和用途. 中国, 授权日: 2016-8-24, 专利号: zl 201410156194.4.