中国医学科学院药物研究所-九游官网下载

主要从事肿瘤/免疫靶向纳米递送系统设计及纳米药物研发和应用研究。主持中国博士后科学基金、北京市自然科学基金、北京市科技新星人才项目、北京市科技新星交叉合作课题、中央高校基本科研业务费及企业关键技术项目，参与十二五、十三五国家科技重大专项以及北京市科委重大基金课题。发表sci论文30余篇，以第一/共一作者在acta pharmaceutica sinica b、bioactive materials、journal for immunotherapy of cancer、journal of nanobiotechnology等药剂及肿瘤免疫主流期刊发表sci论文13篇。申请发明专利13项。获2021年度北京市科学技术奖二等奖（前三）、第十七届中国药学会科学技术奖二等奖（前三）、北京市科技新星、“梁周黄于刘”青年科技奖及北京药学年会优秀论文一等奖。担任北京药学会罕见病药学专委会委员，asian journal of pharmaceutical sciences、chinese chemical letters、acta materia medica杂志青年编委。

肿瘤/免疫靶向纳米递送系统设计及纳米药物研发和应用研究

[1] j. ye, l. li, j. yin, h. wang, r. li, y. yang, y. guan, x. xia, y. liu, tumor-targeting intravenous lipid emulsion of paclitaxel: characteristics, stability, toxicity, and toxicokinetics, j pharm anal, 12 (2022) 901-912.
[2] j. ye, r. li, j. cheng, d. liu, y. yang, h. wang, x. xu, l. li, p. ma, y. liu, comparative colloidal stability of commercial amphotericin b nanoformulations using dynamic and static multiple light scattering techniques, int. j. nanomedicine, 17 (2022) 6047-6064.
[3] j. ye, r. li, y. yang, w. dong, y. wang, h. wang, t. sun, l. li, q. shen, c. qin, x. xu, h. liao, y. jin, x. xia, y. liu, comparative colloidal stability, antitumor efficacy, and immunosuppressive effect of commercial paclitaxel nanoformulations, j nanobiotechnology, 19 (2021) 199.
[4] j. ye, y. gao, m. ji, y. yang, z. wang, b. wang, j. jin, l. li, h. wang, x. xu, h. liao, c. lian, y. xu, r. li, t. sun, l. gao, y. li, x. chen, y. liu, oral smedds promotes lymphatic transport and mesenteric lymph nodes target of chlorogenic acid for effective t-cell antitumor immunity, j immunother cancer, 9 (2021).
[5] j. ye, y. yang, j. jin, m. ji, y. gao, y. feng, h. wang, x. chen, y. liu, targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of tams for the treatment of glioblastoma, bioact. mater., 5 (2020) 694-708.
[6] w. dong, j. ye, j. zhou, w. wang, h. wang, x. zheng, y. yang, x. xia, y. liu, comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein, acta pharm. sin. b, 10 (2020) 1576-1585.
[7] w. dong, j. ye, w. wang, y. yang, h. wang, t. sun, l. gao, y. liu, self-assembled lecithin/chitosan nanoparticles based on phospholipid complex: a feasible strategy to improve entrapment efficiency and transdermal delivery of poorly lipophilic drug, int. j. nanomedicine, 15 (2020) 5629-5643.
[8] j. ye, y. yang, w. dong, y. gao, y. meng, h. wang, l. li, j. jin, m. ji, x. xia, x. chen, y. jin, y. liu, drug-free mannosylated liposomes inhibit tumor growth by promoting the polarization of tumor-associated macrophages, int. j. nanomedicine, 14 (2019) 3203-3220.
[9] j. ye, w. dong, y. yang, h. hao, h. liao, b. wang, x. han, y. jin, x. xia, y. liu, vitamin e-rich nanoemulsion enhances the antitumor efficacy of low-dose paclitaxel by driving th1 immune response, pharm. res., 34 (2017) 1244-1254.
[10] j. ye, x. xia, w. dong, h. hao, l. meng, y. yang, r. wang, y. lyu, y. liu, cellular uptake mechanism and comparative evaluation of antineoplastic effects of paclitaxel-cholesterol lipid emulsion on triple-negative and non-triple-negative breast cancer cell lines, int. j. nanomedicine, 11 (2016) 4125-4140.

[1] 刘玉玲; 叶军; 杨艳芳; 陈晓光; 孟盈盈; 高越; 刘东东; 冯遇; 季鸣; 金晶. 一种免疫靶向功能性脂质体及其制备方法与用途, 2018.10.18, 中国, zl201811212968.5.
[2] 刘玉玲; 杨艳芳; 叶军; 陈晓光; 孟盈盈; 高越; 刘东东; 冯遇; 季鸣; 金晶. 张运; 廖恒锋; 周君卓. 一种绿原酸长循环脂质体及其制备方法和用途, 2018.10.18, 中国, 201811213819.0.
[3] 陈晓光; 刘玉玲; 叶军; 杨艳芳; 高越; 季鸣; 刘东东; 冯遇; 李仁杰; 徐晓燕; 廖恒锋; 李燕; 金晶. 一种自乳化递送系统在制备治疗淋巴转移肿瘤的口服药物中的应用, 2021.07.12, 中国, 202110784259.x.
[4] 刘玉玲; 廖恒锋; 叶军; 刘志华; 高越; 杨艳芳; 廉春放; 刘璐; 徐晓燕; 冯遇; 姜丹; 刘瑾如; 王丽. 黄芩黄酮活性成分及其制剂在制备预防和/或治疗炎症风暴药物中的应用, 2021.12.17, 中国, 202111546224.9.
[5] 刘玉玲; 陈晓光; 杨艳芳; 叶军; 高越; 张运; 廖恒峰; 周君卓; 刘东东; 孟盈盈; 冯遇; 季鸣; 金晶. 一种绿原酸-脂质复合物脂质体及其制备方法和用途, 2020.06.24, 中国, 202010588957.8.
[6] 刘玉玲; 陈晓光; 张洁; 杨艳芳; 叶军; 季鸣; 高越; 李燕; 金晶; 刘东东; 冯遇; 廖恒峰; 周君卓; 姬勋; 杨华蓉; 黄望. 一种绿原酸自乳化组合物及其用途, 2019.06.17, 中国, cn201910523981.0.

1. 刘玉玲，夏学军，叶军，杨艳芳，王洪亮，刘志华，季鸣，高丽丽，高越，孟盈盈，基于复合超分子的脂质纳米载体提高天然药物成药性关键技术及应用，北京市科学技术奖科学技术进步奖二等奖，no.2021-j07-2-02-r03。
2. 刘玉玲，夏学军，叶军，杨艳芳，王洪亮，刘志华，季鸣，高丽丽，高越，孟盈盈，邹媛媛，金毅群，王玉洁，陈晓光，基于复合超分子的脂质纳米载体提高天然药物成药性关键技术及应用，中国药学会科学技术奖二等奖，no.007。