中国医学科学院药物研究所-九游官网下载

2014年在北京协和医学院药物研究所获得博士学位，药物化学专业，导师雷平生研究员。一直从事非天然糖类化合物的合成及糖苷键的构建，对糖类化合物合成、结构解析有着丰富的经验。参与或主持了国家重大新药创制课题-抗g-耐药菌新药的发现与研发的子课题项目；创新药物发现与新技术专项-类具有高抗菌活性的酮内酯类抗生素的合成及生物活性研究；创新工程-复杂天然活性化合物的合成与新药先导物发现研究-任务2。

近五年一直从事非天然糖类化合物的合成及糖苷键的构建，意在发现高活性分子。具体研究方向为含糖苷键活性天然产物结构改造及构效关系研究；硫酸软骨素寡糖全合成、多糖半合成及成药性研究。共计发表sci论文十余篇，申请专利多项。

1. synthesis and antibacterial activity of novel 4′′-o-desosaminyl clarithromycin derivatives with 11, 12-arylalkyl side chains, zhe-hui zhao, di zhu, xiao-xi zhang, zhi-gang luo, ping-sheng lei*,janpr, 2019, 7, 610-618.
2. antibacterial activities of a series of novel 5-o-(4′, 6′-o-dimodified)-mycaminose 14-membered ketolides, zhe-hui zhao, a-peng wang, xiao-xi zhang, shuang yang, zhi-gang luo, ping-sheng lei*, janpr, 2019, 5, 456–461.
3. an efficient and facile approach for construction of chondroitin sulfate e oligosaccharides precursors, guangyan zhang, qi liu, shuang yang, zhehui zhao*, pingsheng lei*, ccl, 30 (2019) 686–689.
4. synthesis of novel 5-o-(6′-o-modified)-desosamine 14-membered ketolides, zhehui zhao, apeng wang, xiaoxi zhang, shuang yang, zhigang luo, pingsheng lei*, ccl, 30 (2019) 425–427.
5. the synthesis and biological evaluation of chondroitin sulfate e glycodendrimers, shuang yang, haijing zhang, qifeng liu, shanshan sun, pingsheng lei, zhehui zhao*, lianqiu wu& yinghong wang, future med. chem. (2019) 11(12), 1403–1415.
6. two novel n-glycoside 17, 18-unsaturated acid quinolin-3-ylmethyl ester josamycin derivatives, zhehui zhao, longlong jin, apeng wang, shuang yang, pingsheng lei, tl, 2018, 59, 1208-1211.
7. synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains, zhe-hui zhao, xiao-xi zhang, long-long jin, shuang yang, ping-sheng lei, bmcl, 2018, 14, 2358-2363.
8. an approach to synthesize chondroitin sulfate-e (cs–e) oligosaccharides precursors, yang, shuang; liu, qi; zhang, guangyan; zhang, xiaoxi; zhao, zhehui*; lei, pingsheng, joc, 2018 83, 5897-5908.
9. synthesis and antibacterial activities of some novel 17, 18-unsaturated carbonyl compounds derivated from josamycin, zhehui zhao†, longlong jin†, yanpeng xu, chao liu, apeng wang, pingsheng lei*, janpr, 2017, 4, 358-387.
10. an investigation of construction of chondroitin sulfate e (cs-e) repeating unit, shuang yang, a-peng wang, guangyan zhang, xiangjie di, zhehui zhao*, pingsheng lei, tetrahedron,72(2016), 5659-5670.
11. synthesis, conformational analysis and sar research of osw-1 analogues, chao liu, a-peng wang, longlong jin, yanshen guo, yan li, zhehui zhao*, pingsheng lei, tetrahedron 72 (2016) 4091-4102.
12. an efficient method to synthesize novel 5-o-(6’-modified)-mycaminose 14-membered ketolide, a-peng wang, chao liu, shuang yang, zhehui zhao*, pingsheng lei*, tetrahedron,72(2016), 285-297.

1， 含有喹啉取代基的红霉素a酮内酯类抗生素衍生物、其制备方法及应用，中国，靳龙龙，雷平生，赵哲辉，zl201410520787.4，20190702。
2， 红霉素a酮内酯类抗生素衍生物、其制备方法及应用，中国，赵哲辉，靳龙龙，雷平生，zl201610118615.3，20191213。
3， 硫酸软骨素多糖半合成制备方法和应用，中国，赵哲辉，雷平生，吴练秋，杨爽，王文杰，张海婧，李想，201910163208.8，20190305。
4， 硫酸软骨素多糖，其半合成制备方法和应用，pct，赵哲辉，雷平生，吴练秋，杨爽，王文杰，张海婧，李想。
5， 7-硝基苯并-2-氧杂-1,3-二唑脱氧氨基葡萄糖、其制备方法及应用，中国，赵哲辉，申竹芳，环奕，雷平生，杨爽，刘帅男，李彩娜，201811501558.2，20181210.
6， 含有氨基喹啉环的高抗菌活性红霉素a酮内酯类抗生素衍生物、其制备方法及应用，中国，赵哲辉，雷平生，张晓曦，杨爽，201811216765.3，20181018.硫酸软骨素寡糖、其制备方法和应用，中国，赵哲辉，刘启，张广艳，杨爽，王瑛璞，雷平生，201810033328.1，20180115.