中国医学科学院药物研究所-九游官网下载

一、 工作经历
2018.10-至 今 中国医学科学院药物研究所 副研究员
2015.09-2018.09 中国医学科学院药物研究所 助理研究员
2013.08-2015.07 美国加州州立大学 博士后研究员
二、教育背景
2009.09-2013.06 上海交通大学药学院 博士
2006.09-2009.06 中国药科大学药学院 硕士
2001.09-2005.06 海南师范大学化学系 本科
三、在研项目
靶向hedgehog通路新型菲骈吲哚里西啶抗神经胶质瘤化合物的设计、合成及机制研究，国家自然科学基金面上项目，2021.1-2024.12，负责人

1. 活性天然产物的发现、结构优化与成药性研究
2. 多手性中心活性天然产物及其异构体的全合成
2006年至今一直从事药物化学领域研究工作，主要涉及活性天然产物的发现、结构修饰、全合成及新合成方法学研究。研究工作目前累计发表研究论文近50篇，包括以第一或通讯作者发表在本领域主流期刊chemical science、journal of medicinal chemistry、organic letter、european journal of medicinal chemistry等研究论文近30篇，申请中国发明专利12项，获得授权专利9项，申请pct专利1项并分别获得美国和欧盟授权。

1. jinyao yong#, mi li#, wenrui li#, rongmei gao, guozhu su, haiqiang wang, jia yang, li li, yuhuan li, peter scott, rubing wang*, xiaojing wang*, shuanggang ma*. seco-sesquiterpenes and acorane-type sesquiterpenes with antiviral activity from the twigs and leaves of illicium henryi diels. bioorg. chem. 2023, 131: 106324.
2. zifan feng, shanshan zhu, wenrui li, maojun yao, hualong song*, rubing wang*. current approaches and strategies to identify hedgehog signaling pathway inhibitors for cancer therapy. eur. j. med. chem. 2022, 244: 114867.
3. rubing wang#, shuanggang ma#*, cooper s. jamieson#, rongmei gao, yunbao liu, yong li, xiaojing wang, yuhuan li, kendall n. houk*, jing qu*, shishan yu*. library construction of stereochemically diverse isomers of spirooliganin: their total synthesis and antiviral activity. chem. sci. 2021, 12: 7003-7011.
4. jinyao yong#, wenrui li#, xiaojing wang, guozhu su, mi li, jianpei zhang, hongli jia, yuhuan li, rubing wang*, maoluo gan*, shuanggang ma*. illihenin a, an antiviral sesquiterpenoid with a cage-like tricyclo[6.2.2.01,5]dodecane skeleton from illicium henryi. j. org. chem. 2021, 86: 2017-2022.
5. qingyun fang, haishan jin, rubing wang*, liming zhao*. a role for isatin azomethine imines as a dipolarophile in cycloaddition reactions. org. lett. 2020, 22: 7358-7362.
6. rubing wang#, xiaodong ren#, jie he, shanshan zhu, huiru xie, guozhu su, shuanggang ma, shishan yu*. burchellin and its stereoisomers: total synthesis, structural elucidation and antiviral activity. org. biomol. chem. 2020, 18: 9081-9087.
7. qingyun fang, haishan jin, rubing wang*, liming zhao*. dabco-mediated [3 3] cycloaddition of azomethine imines with in situ generated nitrile oxides from hydroximoyl chlorides. chem. comm. 2019, 55: 10587-10591.
8. rubing wang, haining lv, shanshan zhu, xiaodong ren, song xu, shuanggang ma, yunbao liu, jing qu*, shishan yu*. a novel and practical synthesis of cat3: a phenanthroindolizidine alkaloid with potential in treating glioblastoma. rsc adv. 2018, 8: 29301-29308.
9. rubing wang, xiaojie zhang, chengsheng chen, guanglin chen,cristian sarabia, qiang zhang, shilong zheng, guangdi wang, qiaohong chen*. structure-activity relationship studies of 1,7-diheteroarylhepta-1,4,6-trien-3-ones with two different terminal rings in prostate epithelial cell models. eur. j. med. chem. 2017, 133: 208.
10. rubing wang, chengsheng chen, xiaojie zhang, guanglin chen, qiang zhang, shilong zheng, guangdi wang, qiaohong chen*. synthesis and evaluation of 1,7- diheteroarylhepta-1,4,6-trien-2-ones as promising anticancer agents. eur. j. med. chem. 2016, 110: 16.
11. rubing wang, chengsheng chen, xiaojie zhang, changde zhang, guanglin chen, qiang zhang, shilong zheng, guangdi wang, qiaohong chen*. structure-activity relationship and pharmacokinetic studies of 1,5-diheteroarylpenta-1,4-dien-3-ones: a class of curcumin-based anticancer agents. j. med. chem. 2015, 58: 4713-4726.

1. 菲并吲哚里西啶生物碱衍生物纳米自乳化组合物及其制备方法. 中国发明专利，授权号 cn 112353759b, 授权日期2023.4.11
2. 菲并吲哚里西啶生物碱衍生物固体脂质纳米粒组合物. 中国发明专利，授权号 cn 112870178b, 授权日期2023.1.6
3. 13a-(s)-3-新戊酰氧基-6,7-二甲氧基菲骈吲哚里西啶的晶b型. 中国发明专利，授权号 cn 110117279b, 授权日期2021.5.11
4.光学纯(s)-3-新戊酰氧基-6,7-二甲氧基菲并吲哚里西啶的制备. 中国发明专利，授权号 cn 110294752b, 授权日期2021.1.11