中国医学科学院药物研究所-九游官网下载

王亚男，男，博士，副研究员，硕士研究生导师，分析室党支部书记。2012年8月进入中国医学科学院药物研究所药物分析研究室核磁组工作至今。主要从事核磁共振分析新技术新方法在新药研发中的应用与创新，建立了领先的以活性结构为导向的基于液相-核磁共振联用技术高效快速发现天然产物活性物质的应用分析策略。目前承担北京协和医学院《波谱解析（硕士）》、《药物分析》、《药物化学实验》研究生课程授课，其中《波谱解析》在2018年被评为全国医药学研究生精品建设课程，《药物分析》荣获2022年北京协和医学院研究生精品课程。曾参与承担国家“863”项目、国家重点研发计划、国家重点研发计划政府间合作、国家自然科学基金等项目。在analytical chemistry、acta pharm sin b、j control release等国际知名期刊发表sci论文50余篇，获得授权专利3项，申请专利3项，软件著作权1项。参与编写《分析化学手册. 7a. 氢-1核磁共振波谱分析（第三版）》及《药物分析技术进展与应用》专业书籍。1项教学案例入选全国药学专业学位研究生教育指导委员会第五届全国药学专业学位优秀教学案例。担任marinedrugs、chinese chemical letters、journal of asian natural products research、antioxidants、pharmaceutics、genes、journal of ethnopharmacology、phytochemistry、frontiers in microbiology等学术期刊同行评议人。兼任北京理化分析测试技术学会波谱专业委员会理事、中国医药生物技术协会药物分析技术分会委员、中国中药信息学会临床研究分会常务理事、《中国药物化学杂志》首届青年编委、《asian journal of traditional medicines》首届青年编委。

1.核磁共振代谢组学分析技术在药物研发中的应用研究
2.核磁共振分析新技术新方法及其在药物研发中的应用研究
3.基于液相-核磁共振联用技术的活性物质快速发现研究

1. dongyang zhao#, kaijing guo#, qian zhang, yan wu, chen ma, wenyi he, xiangju jin, xinyu zhang, yanan wang,* sheng lin,* hongcai shang, mechanism of xijiaqi in the treatment of chronic heart failure: integrated analysis by pharmacoinformatics, molecular dynamics simulation, and spr validation. computers in biology and medicine, 2023.
2. xinjian li, zhe wang, bowen zheng, yanan wang,* and jinlan zhang*, novel strategy to rapidly profile and identify oxidized species of polysorbate 80 using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry. analytical chemistry, 2023.
3. lingyan wanga, guiyang xiaa, huan xia, xiaohong wei, yanan wang, sheng lin*, (d)/(l)-yanhusamides alc, three pairs of unprecedented benzylisoquinoline-pyrrole hetero-dimeric alkaloid enantiomers from corydalis yanhusuo. acta pharmaceutica sinica b, 2023.
4. tian, m.#; wang, y.-n.#; lu, a.; zhang, q.; li, x.; zhang, n.; zhang, j.; wang, s., from metabolomic analysis to quality assessment and biosynthetic insight in traditional chinese medicine: mulberry tree as a case study. phytochemical analysis, 2022.
5. nmr-based metabolomic approach to understanding zeng-sheng-ping-induced hepatotoxicity, and identifying possible toxic constituents by lc-ms profiles. wu, y.; wang, j.-q.; wang, y.-n.; pang, x.-x.; bao, j.; guan, x.-b.; wang, s.-j., journal of pharmaceutical and biomedical analysis, 2022.
6. zhang, d. y.; zhou, j. j.; yang, h.; wang, m.; wang, y. n.; liu, s.; zhang, z. m.; zhuang, p. y.; wang, x. x.; liu, h., chlorahupetenes a-d, four eudesmane-type sesquiterpenoid dimer enantiomers with two unusual carbon skeletons from chloranthus henryi var. hupehensis. journal of organic chemistry 2022.
7. wang, l.; xia, g.; xia, h.; wei, x.; wang, y.; lin, s., ( )/(−)-yanhusamides a−c, three pairs of unprecedented benzylisoquinoline-pyrrole hetero-dimeric alkaloid enantiomers from corydalis yanhusuo. acta pharmaceutica sinica b, 2022.
8. pei, y.-h.; zhang, l.-h.; wu, x.-l.; wu, h.-h.; wang, h.-f.; wang, y.-n.; chen, g., polyhydroxylated bergamotane-type sesquiterpenoids from cultures of paraconiothyrium sporulosum yk-03 and their absolute configurations. phytochemistry, 2022.
9. xenoacremones d–h, bioactive tyrosine-decahydrofluorene analogues from the plant-derived fungus xenoacremonium sinensis. liu, z.; liu, l.; wang, a.; li, l.; zhao, s.; wang, y.-n.; sun, y., marine drugs, 2022.
10. nine sesquiterpenoid dimers with four unprecedented types of carbon skeleton from chloranthus henryi var. hupehensis. zhang, d.-y.; wang, x.-x.; wang, y.-n.; wang, m.; zhuang, p.-y.; jin, y.; liu, h., organic chemistry frontiers, 2021.
11. xanthanoltrimer a–c: three xanthanolide sesquiterpene trimers from the fruits of xanthium italicum moretti isolated by hplc-ms-spe-nmr. fu, j.; wang, y.-n.; ma, s.-g.; li, l.; wang, x.-j.; li, y.; liu, y.-b.; qu, j.; yu, s.-s., organic chemistry frontiers, 2021.
12. a fast strategy for profiling and identifying pharmaceutic excipient polysorbates by ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry. wang, z.#; wang, y.-n.#; tie, c.; zhang, j.-l., j chromatogr a, 2020.
13. insight into medicinal chemistry behind traditional chinese medicines: p-hydroxybenzyl alcohol-derived dimers and trimers from gastrodia elata. wang, y.; zhang, m.; zhou, x.; xu, zhu, c.; yuan, y.; chen, n.; yang, y.; guo, q.; shi, j., natural products and bioprospecting, 2020.
14. trichodestruxins a–d: cytotoxic cyclodepsipeptides from the endophytic fungus trichoderma harzianum. liu, z.; sun, y. *; tang, m.; sun, p.; wang, a.; hao, y.; wang, y.*; pei, y.*,journal of natural products, 2020.
15. enzymatic intermolecular hetero-diels-alder reaction in the biosynthesis of tropolonic sesquiterpenes. chen, q.; gao, j.; jamieson, c.; liu, j.; ohashi, m.; bai, j.; yan, d.; liu, b.; che, y.; wang, y.; houk, k. n.; hu, y., j am chem soc, 2019.

1. 《药物分析技术进展与应用》，编者，中国协和医科大学出版社，2021.
2. 《分析化学手册. 7a. 氢-1核磁共振波谱分析（第三版）》，编者，化学工业出版社，2016.