中国医学科学院药物研究所-九游官网下载

张青扬，博士，副研究员，硕士生导师。2013年毕业于中国医学科学院&北京协和医学院药物研究所，获药物化学博士学位。2015年进入中国医学科学院药物研究所工作，专注于分子探针构建及功能化、创新药物发现新策略等方面的研究工作。先后主持了国家自然科学基金青年基金项目和面上项目、北京市自然科学基金面上项目、并作为任务负责人参与了中国医学科学院医学与健康科技创新工程项目。近年来，以第一作者或通讯作者身份发表sci论文十余篇，申请专利11项，授权专利4项，并参与编译了《化学生物学》教材。

以化学生物学为基础，从事分子探针的设计、合成及功能化研究，旨在针对细菌感染、肿瘤及细胞衰老相关疾病进行新型治疗、检测试剂的研发，并深入探究其分子机制。具体研究内容包括：1. 响应型荧光分子探针的设计、合成及功能化研究；2. 基于分子探针的细菌感染相关物质检测及作用机制研究；3. 热激活延迟荧光分子驱动的荧光时间分辨成像及生物学应用；4. 基于新策略的创新药物研发。

1. xiang wang#, gaona shi#, shengnan xu, yuansheng sun, hailin qiu, qinghua wang, xiaowan han, qingyang zhang*, tiantai zhang*, and hai-yu hu*. unravelling immune-inflammatory responses and lysosomal adaptation: insights from two-photon excited delayed fluorescence imaging. adv. healthcare mater. 2024, 2304223.
2. xiaowan han#, xiangchuan meng#, xiang wang#, shan leng, qian liu, leilei zhang, pingping li, qingyang zhang*, and hai-yu hu*. analyte-triggered excited-state intramolecular proton transfer delayed fluorescence: a general approach for time-resolved turn-on fluorescence imaging. analytical chemistry 2023, 95, 7715−7722.
3. qian liu#, miao yang#, xiangchuan meng, xiaowan han, marc nazare, youjun xu,* hai-yu hu,* and qingyang zhang*. donor manipulation for constructing a ph sensing thermally activated delayed fluorescent probe to detect alkaliphiles. talanta 2022, 246, 123493.
4. shengnan xu#, qingyang zhang#, xiaowan han, yali wang, xiang wang, marc nazare, jian-dong jiang,* and hai-yu hu*. dual-mode detection of bacterial 16s ribosomal rna in tissues. acs sensors 2020, 5, 1650-1656.
5. na zhang#, yali wang#, shan leng#, shengnan xu, leilei zhang, qinghua wang, qingyang zhang* and hai-yu hu*. an efficient fluorescence sensor for nitroreductase selective imaging based on intramolecular photoinduced electron transfer. talanta 2019, 205, 120133.
6. qingyang zhang#, shengnan xu#, meng li#, yali wang, na zhang, yan guan, mingxing chen, chuan-feng chen* and hai-yu hu*. rationally designed organelle-specific thermally activated delayed fluorescence small molecular organic probes for time-resolved biological applications. chemical communications 2019, 55, 5639-5642.
7. qingyang zhang#, shengnan xu#, fangfang lai#, yali wang, na zhang, marc nazare, and hai-yu hu*. rapid synthesis of γ-halide/pseudohalide-substituted cyanine sensors with programmed generation of singlet oxygen. organic letters 2019, 21 (7), 2121-2125.
8. yubin ji#, yali wang#, na zhang#, shengnan xu, leilei zhang, qinghua wang, qingyang zhang* and hai-yu hu*. cell-permeable fluorogenic probes for identification and imaging nitroreductases in live bacterial cells. the journal of organic chemistry 2019, 84 (3), 1299-1309.
9. qingyang zhang#, qinghua wang#, yin sun; liming zuo, verena fetz, hai-yu hu*. superior fluorogen-activating protein probes based on 3-indole-malachite green. organic letters 2017, 19, 4496-4499.
10. qingyang zhang#, qinghua wang#, shengnan xu, limin zuo, xuefu you, haiyu hu*. aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications. chemical communications 2017, 53 (8), 1366-1369.

1. 超敏感荧光探针检验细菌中硝基还原酶及在细菌感染应用，中国医学科学院药物研究所，2019-10-231.
2．一种热激活延迟荧光探针分子、其制备及其在细胞成像中的应用，中国医学科学院药物研究所，2019-3-041.
3．热激活延迟荧光( tadf )纳米探针及其制备方法和在生物成像中的应用，哈尔滨医科大学，2018-11-08