中国医学科学院药物研究所-九游官网下载

卢诗超，山东济南人。2013年毕业于北京协和医学院&中国医学科学院药物研究所，获得药物化学博士学位。2013至2015年在北京生命科学研究所/北京大学医学部从事博士后研究。目前主要从事基于微量、复杂、活性天然产物的化学合成及新药研发工作。近年来，作为项目负责人主持了国家自然科学基金、北京市自然科学基金、北京市博士后科研活动经费资助项目、中央级公益性科研院所基本科研业务费（创新人才专项）、北京大学天然药物及仿生药物国家重点实验室开放研究课题；参与中国医学科学院医学与健康科技创新工程重大协同创新项目；作为第一作者或通讯作者在angewandte chemie international edition, green chemistry, organic letters等国际著名期刊发表论文10余篇；以主要完成人获得中国药学会科技进步一等奖；申请发明专利2项。

1. 发展合成复杂活性天然产物的新策略和新模式，突破由复杂活性天然产物进行新药创制的关键瓶颈；
2. 发展新型的合成方法学，解决复杂结构的高效构建、药物分子后期精准修饰等问题。

1. jia-xuan liu,# shi-peng zhang,# feng-sen sun, hui li, ya-ling gong,* shi-chao lu,* shu xu,* asymmetric total synthesis of naphthospironone a. angew. chem. int. ed. 2023, https://doi.org/10.1002/anie.202303229. (if = 16.823)
2. shi-chao lu,# fu-qiang wen,# xi-dong guan,* a formal metal-free γ-arylation of 1,3-dicarbonyl compounds via a sequence of isomerization/1,4-addition/[3,3]- sigmatropic rearrangement. green chem. 2021, 23, 8964−8968. (if = 11.034)
3. hong-shuang li,# shi-chao lu,# zhi-xin chang, liqiang hao, fu-rong li, chengcai xia, rhodium-catalyzed ring-opening hydroacylation of alkylidenecyclopropanes with chelating aldehydes for the synthesis of γ,δ-unsaturated ketones. org. lett. 2020, 22, 5145−5150. (if = 6.005)
4. shi-chao lu,# yu-yan liang,# liang li,# xiao-lei wang, shi-peng zhang, ya-ling gong, shu xu,* synthesis of the tricyclic caged core of palhinine alkaloids based on a non-diels−alder-type strategy. org. lett. 2019, 21, 5567−5569. (if = 6.091)
5. shi-chao lu,# zhi-xin chang,# yu-liang xiao, hong-shuang li,* regio- and stereoselective synthesis of 2-hydroxymethyl-1,3-enynes by rhodium-catalyzed decarboxylative c−c coupling. adv. synth. catal. 2019, 361, 4831−4836. (if = 5.851)
6. jie wu,# ran mu,# zi-jie liu, shi-chao lu,* gang liu,* scalable total synthesis of a mycobactin t analogue utilizing a novel synthetic and protection strategy. org. chem. front. 2019, 6, 2467–2470. (if = 5.155)
7. shi-chao lu, hong-shuang li,* ya-ling gong, shi-peng zhang, ji-guo zhang, shu xu,* combination of phi(oac)2 and 2-nitropropane as the source of methyl radical in room-temperature metal-free oxidative decarboxylation/cyclization: construction of 6-methyl phenanthridines and 1-methyl isoquinolines. j. org. chem. 2019, 83, 15415−15425. (if = 4.745)
8. shi-chao lu, hong-shang li*, shu xu, gui-yun duan, silver-catalyzed c2-selective direct alkylation of heteroarenes with tertiary cycloalkanols. org. biomol. chem. 2017, 15, 324−327. (if = 3.423)
9. shi-chao lu, hong-shuang li,* ya-ling gong, xiao-lei wang, fu-rong li, fei li, gui-yun duan, shu xu,* use of unprotected amino acids in metal-free tandem radical cyclization reactions: divergent synthesis of 6-alkyl/acyl phenanthridines. rsc adv. 2017, 7, 55891−55896. (if = 2.936)
10. shi-chao lu,* yaling gong, demin zhou, transition metal-free oxidative radical decarboxylation/cyclization for the construction of 6 alkyl/aryl phenanthridines. j. org. chem. 2015, 80, 9336−9341. (if = 4.721)

1. 许述，纪春阳，弓亚玲，卢诗超，张世鹏，一种盐酸普拉克索有关物质的制备方法，2022-05-07，中国，202210488858.1
2. 许述，孙艺菁，张世鹏，弓亚玲，卢诗超，一种派恩加滨的制备方法，2023-02-21，中国，2023101426299