中国医学科学院药物研究所-九游官网下载

潘璇 博士，副研究员，硕士生导师，1987年1月3日出生。本科毕业于浙江大学药学院，博士毕业于北京协和医学院。2014年进入中国医学科学院药物研究所工作，2019年聘任为副研究员，主要从事创新药物研发、天然产物全合成、有机合成方法学等方面的工作。主持或参与科研项目8项，其中主持国家自然青年基金项目1项，中央级公益性科研院所基本科研业务费2项，参与的项目包括国家科技重大专项3项、重点实验室自主课题1项、高等学校博士学科点专项科研基金1项。2020年获得药物所“梁周黄于刘”青年科技三等奖。近年来，发表sci论文20余篇，申请发明专利9项，授权3项。

1. 创新药物的研究与开发
以具有强生物活性的天然产物为结构先导物，利用全合成手段，设计、合成具有生物活性的结构类似物，以期能够发现具有自主知识产权的创新药物。
2. 生物活性天然产物全合成
致力于建立高效的天然产物全合成方法，解决天然产物来源，为后续结构改造奠定基础。
3. 有机合成方法学研究
开发高效的有机化学合成新方法，包括基于苯炔化学构建药物化学常见骨架、使用有机小分子实现常见有机反应的不对称催化等。

1. asymmetric total synthesis of griseofamine b and its three stereoisomers, tao sheng, caiyun ma, guangyan zhang, xuan pan*, zhanzhu liu*, journal of natural products, 2022, 85(4), 1128-1133.
2. the asymmetric total synthesis of (−)-eurothiocin a and its enantiomer, guangyan zhang, xuan pan, beibei yang, li li, zhanzhu liu*, journal of natural products, 2022, 85(4), 997-1005.
3. design, synthesis and biological evaluation of exiguamine a analogues as ido1 inhibitors, junmin dong, xuan pan, ying yang, guangyan zhang, zhiyan xiao, zhanzhu liu*, european journal of medicinal chemistry, 2021, 223, 113631-113645.
4. an improved total synthesis of griseofamine a, xuan pan‡， rui yu‡, zhanzhu liu*,tetrahedron letters, 2021, 67, 152894-152895.
5. synthesis and cytotoxicity of (−)-homorenieramycin g and its derivatives, yantao ma, xuan pan*, baohe guan, guangyan zhang, zhanzhu liu*, organic & biomolecular chemistry, 2020, 18, 9883-9894.
6. design, synthesis and cytotoxicity of novel hexacyclic saframycin–ecteinascidin analogs, xiangran lu, xuan pan, baohe guan, zhanzhu liu*, organic & biomolecular chemistry, 2020, 18, 237-249.
7. regioselective bromination of 6-hydroxytetrahydroisoquinolines, ke wang, xuan pan, kun peng, zhanzhu liu*, journal of heterocyclic chemistry, 2020, 1-4.
8. total synthesis and antibacterial activity evaluation of griseofamine a and 16-epi-griseofamine a, xuan pan, zhanzhu liu*, organic letters, 2019, 21(7), 2393-2396.
9. a novel specific peroxisome proliferator-activated receptor γ (pparγ) modulator yr4-42 ameliorates hyperglycaemia and dyslipidaemia and hepatic steatosis in diet-induced obese mice, yi huan‡, xuan pan‡, jun peng, chunming jia, sujuan sun, guoliang bai, xing wang, tian zhou, rongcui li, shuainan liu, caina li, quan liu, zhanzhu liu*, zhufang shen*, diabetes obesity & metabolism, 2019, 2553-2563.
10. a concise synthesis of (e)-3-aryl-2,3,4,5-tetrahydro-1h-3-benzazonines by aryne induced [2,3] stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines, xuan pan‡, yantao ma‡, zhanzhu liu*, organic & biomolecular chemistry, 2018, 16(40), 7393-7399.
11. synthesis of 3-aryl-3-benzazepines via aryne [1,2] stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines, xuan pan, zhanzhu liu*, organic chemistry frontiers, 2018, 5(11), 1798-1810.
12. synthesis and cytotoxicity of novel imidazo[4,5-d]azepine compounds derived from marine natural product ceratamine a, xuan pan‡, lulu tao‡, ming ji, xiaoguang chen, zhanzhu liu*, bioorganic & medicinal chemistry letters, 2018, 28(5), 866-868.
13. asymmetric synthesis of highly functionalized tyrosine derivatives for the construction of bistetrahydroisoquinoline alkaloids, enming du, xuan pan, baohe guan, zhanzhu liu*, tetrahedron letters, 2018, 59(31), 3029-3032.
14. design, synthesis and biological evaluation of a series of novel gpr40 agonists containing nitrogen heterocyclic rings, zhaozhu sun, tian zhou, xuan pan, ying yang, yi huan, zhiyan xiao, zhufang shen*, zhanzhu liu*, bioorganic & medicinal chemistry letters, 2018, 28(18), 3050-3056.
15. synthesis and cytotoxicity of a novel series of saframycin-ecteinascidin analogs containing tetrahydro-β-carbboline moieties, xiangran lu, xuan pan, ying yang, ming ji, xiaoguang chen, zhiyan xiao, zhanzhu liu*, european journal of medicinal chemistry, 2017, 135(28), 260-269.
16. effective synthesis and cytotoxicity of novel microtubule-stabilizing agent ceratamine a analogues, lulu tao, xuan pan**, ming ji, xiaoguang chen, zhanzhu liu*, tetrahedron, 2017, 73(15), 2159-2171.
17. stereoselective total synthesis of (±)-parthenolide and (±)-7-epiparthenolide, liang li, xuan pan, baohe guan, zhanzhu liu*, tetrahedron, 2016, 72, 4346-4354.
18. synthesis and biological evaluation of novel tetrahydroisoquinoline-c-aryl glucosides as sglt2 inhibitors for the treatment of type 2 diabetes, xuan pan, yi huan, zhufang shen, zhanzhu liu*, european journal of medicinal chemistry, 2016, 114, 89-100.
19. synthesis of indolo[2,3-a]pyrrolo[3,4-c]carbazoles via the oxidative cyclization of bisindolylmaleimides with pd(tfa)2/cu(oac)2, xuan pan, ke wang, baohe guan, zhanzhu liu*, journal of heterocyclic chemistry, 2015, 52, 911-913.
20. asymmetric total synthesis of three stereoisomers of (-)-renieramycin g and their cytotoxic activities, enming du, wenfang dong, baohe guan, xuan pan, zheng yan, li li, nan wang, zhanzhu liu*, tetrahedron, 2015, 71, 4296-4303.
21. the preparation of novel chiral auxiliaries samiq/ramiq and their application in the asymmetric michael addition, xuan pan, zhanzhu liu*, tetrahedron, 2014, 70, 4602-4610.

1. 一类吲哚-特特拉姆酸化合物、其制备和医药用途，刘站柱，潘璇，胡海宇，马彩云，于瑞，张广艳，贯宝和，魏娆，王晋阳，申请号：202310247411x，申请日：2023年03月15日。
2. 一类抗肿瘤天然产物ecteinascidins结构类似物的制备和医药用途，刘站柱，陈晓光，鲁向冉，潘璇，季鸣，贯宝和，专利号：zl201810298367.4，授权公告日：2021年04月13日。
3. 一类四氢异喹啉化合物及其盐的制备和医药用途，刘站柱，申竹芳，于然，贯宝和，彭军，潘璇，刘泉，刘率男，孙素娟，李彩娜，孙兆柱，贾春明，姜茜，王悦，周艳丽，专利号：zl201611207052.1，授权公告日：2021年04月13日。
4. 一类ido1抑制剂的制备和用途，刘站柱，潘璇，董俊敏，张广艳，贯宝和，申请号：202110313379.1，申请日：2021年03年24日。
5. 一类含中环四氢咔啉-四氢异喹啉化合物的制备和用途，刘站柱，马艳涛，潘璇，贯宝和，张广艳，于瑞，申请号：202010258549.6，申请日：2020年04年03日。
6. 一类含中环的renieramycin g衍生物的制备和用途，刘站柱，马艳涛，潘璇，贯宝和，张广艳，于瑞，申请号：202010229704.1，申请日：2020年03年27日。
7. 钠糖共转运体2抑制剂、其制法和其药物组合物与用途，刘站柱，申竹芳，潘璇，环奕，刘泉，王悦，专利号：zl201410218852.8，授权公告日：2019年07月02日。
8. 一类四氢咔啉－四氢异喹啉化合物的制备和医药用途，刘站柱，陈晓光，鲁向冉，潘璇，季鸣，贯宝和，申请号：201811266399.2，申请日：2019年05月07日。
9. gpr40 受体激动剂、其制法和其药物组合物与用途，刘站柱，申竹芳，孙兆柱，潘璇，周甜，环奕，贯宝和，申请号：201810234530.0，申请日：2018年03月21日。