中国医学科学院药物研究所-九游官网下载

教育背景
北京大学医学部基础医学专业 学士
北京大学医学部神经生物学 博士
工作经历
北京大学中国药物依赖性研究所 博士后
中国医学科学院药物研究所 助理研究员、副研究员
作为课题负责人主持国家自然科学基金青年基金项目、面上项目等项目、国家重点研发计划课题/子课题，作为主要研究人员参与新药重大创制专项、国家自然科学基金重大研究计划培育项目等研究多项。发表中英文论文多篇，参与编译多部学术专著，包括《julien精神药理学》、《沈渔邨精神病学》、《神经生物学》等。

主要从事神经精神疾病的发病机制及治疗研究。研究方向包括药物成瘾、应激相关疾病如抑郁症以及神经系统疾病如多发性硬化症的发病机制及治疗等。

1. hongwan ding*, yinge gao*, ying wang*, kaiyun yao , guibin wang# , jianjun zhang#. the role of peripheral serotonin and norepinephrine in the gastroprotective effect against stress of duloxetine. eur j pharmacol. 2023 feb 15;941:175499 doi: 10.1016/j.ejphar.2023.175499.
2. yang chen*, guibin wang*, wen zhang, ying han, libo zhang, hubo xu, shiqiu meng, lin lu#, yanxue xue#, jie shi#. an orbitofrontal cortex-anterior insular cortex circuit gates compulsive cocaine use. science advances, 2022 dec 23;8(51):eabq5745. doi: 10.1126/sciadv.abq5745.
3. yang chen, libo zhang, zengbo ding, xianwen wu, guibin wang#, jie shi#. effects of 3-methylmethcathinone on conditioned place preference and anxiety-like behavior: comparison with methamphetamine. front mol neurosci. 2022 jul 22;15:975820. (# co-response author )
4. kaiyun yao*, cao linyu*, ding hongwan*, gao yinge, li tiegang; wang guibin#, zhang jianjun#. increasing aspartoacylase in the central amygdala: the common mechanism of gastroprotective effects of monoamine-based antidepressants against stress. front pharmacol.2022 feb 25;13: 823291. (# co-response author )
5. linyu cao, xulin li, ruiming xu, kaiyun yao, wanqi yang, hongliang zhu, guibin wang#, jianjun zhang#. duox2, a common modulator in preventive effects of monoamine-based antidepressants on water immersion restraint stress- and indomethacin- induced gastric mucosal damage european journal of pharmacology 2020 jun 5;876:173058. doi: 10.1016/j.ejphar.2020.173058.
6. yan sun*, guibin wang*, qixiang lin*, lin lu, ni shu, shiqiu meng, jun wang, hongbin han, yong he, jie shi. disrupted white matter structural connectivity in heroin abusers. addict biol. 2017 jan;22(1):184-195. doi: 10.1111/adb.12285.
7. yan sun*, liyan zhao*, guibin wang, weihua yue, yong he, ni shu, qixiang lin, fan wang, jiali li, na chen, huimin wang, thomas r kosten 8, jiajia feng, jun wang, yu-de tang, shu-xue liu, gui-fa deng, gan-huan diao, yun-long tan, hong-bin han, lu lin, jie shi. znf804a variants confer risk for heroin addiction and affect decision making and gray matter volume in heroin abusers. addict biol. 2016 may;21(3):657-66. doi: 10.1111/adb.12233.
8. peng li , ping wu, xue xin, yun-li fan, guibin wang, fan wang, meng-ying ma, ming-ming xue, yi-xiao luo, fu-de yang, yan-ping bao, jie shi, hong-qiang sun, lin lu incubation of alcohol craving during abstinence in patients with alcohol dependence. addict biol. 2015 may;20(3):513-22. doi: 10.1111/adb.12140.
9. guibin wang, jie shi, na chen, lingzhi xu, jiali li, peng li, yan sun, lin lu. effects of length of abstinence on decision-making and craving in methamphetamine abusers. plos one. 2013 jul 24;8(7):e68791. doi: 10.1371/journal.pone.0068791.
10. xiao-li zhang*, guibin wang*, li-yan zhao, li-li sun, jun wang, ping wu, lin lu, jie shi. clonidine improved laboratory-measured decision-making performance in abstinent heroin addicts plos one. 2012;7(1):e29084. doi: 10.1371/journal.pone.0029084.
11. guibin wang*, xiao-li zhang*, liyan zhao, lili sun, ping wu, lin lu, jie shi. drug-related cues exacerbate decision making and increase craving in heroin addicts at different abstinence times. psychopharmacology (berl). 2012 jun;221(4):701-8. doi: 10.1007/s00213-011-2617-5.
12. xiaoli zhang, jie shi, liyan zhao, lili sun, jun wang, guibin wang, david h epstein, lin lu. effects of stress on decision-making deficits in formerly heroin-dependent patients after different durations of abstinence am j psychiatry. 2011 jun;168(6):610-6. doi: 10.1176/appi.ajp.2010.10040499.
13. guibin wang, liu-zhen wu, peng yu, yi-jing li, xing-jie ping, cai-lian cui. multiple 100 hz electroacupuncture treatments produced cumulative effect on the suppression of morphine withdrawal syndrome: central preprodynorphin mrna and p-creb implicated peptides. 2011 apr;32(4):713-21. doi: 10.1016/j.peptides.2010.12.006.
14.曹琳玉, 丁虹琬, 姚开云, 张建军, 王贵彬 n-乙酰天冬氨酸在中枢神经系统中的研究进展，药学学报 2020, 55(8): 1754-1761
15.姚开云, 丁虹琬, 曹琳玉, 高银阁, 张建军, 王贵彬 组蛋白去乙酰化酶抑制剂的抗抑郁前景，药学学报 2021, 56(1): 29-36