中国医学科学院药物研究所-九游官网下载

副研究员，硕士生导师。2001年本科毕业于山东大学药学院，2004年获得山东省医学科学院药物研究所天然药物化学专业硕士学位，2008年获得中国医学科学院药物研究所药物化学专业博士学位。近年来，以质谱在生物医药中的应用研究为基础，结合化学生物学以及药物化学开展了抗肿瘤、抗糖尿病小分子抑制剂研究以及有机小分子探针生物成像应用研究。主持或参与科研项目共10项，其中主持国家自然青年基金项目1项，药物所基本科研业务费1项，参与的项目包括国家科技重大专项3项，国自然面上项目3项等。迄今在analytical chemistry，acta pharmaceutica sinica b，chemical communications，journal of medicinal chemistry 等期刊发表论文10余篇。

1.质谱分析应用研究；
2.有机小分子探针生物成像应用研究

1. a single component self-assembled thermally activated delayed fluorescence nanoprobe, rao wei†, leilei zhang†, shengnan xu, qingyang zhang, yongxiu qi*, hai-yu hu*, chemical communications, 2020，56(17): 2550-2553.
2. gadolinium-labeled aminoglycoside and its potential application as a bacteria-targeting magnetic resonance imaging contrast agent, leilei zhang†, yun liu†, qingyang zhang, tiegang li, min yang, qingqiang yao, xilei xie, hai-yu hu*, analytical chemistry, 2018，90(3): 1934-1940.
3. a novel nitroreductase-enhanced mri contrast agent and its potential application in bacterial imaging, yun liu, leilei zhang*, marc nazare, qingqiang yao*, hai-yu hu*, acta pharmaceutica sinica b, 2018，8(3): 401-408.
4. identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (tssk1) by the developed assays, leilei zhang, yan yu, zijie liu, zeper abliz, gang liu*, journal of medicinal chemistry, 2009, 52, 4419-4428.
5. identification of 3, 5, 6-substituted indolin-2-one’s inhibitors of aurora b by development of a luminescent kinase assay, leilei zhang, tianming yang, xilei xie, gang liu*, bioorganic & medicinal chemistry letters, 2015, 25, 2937-2942.
6. simultaneous quantification of six major triterpenoid saponins in schefflera kwangsiensis using high-performance liquid chromatography coupled to orbitrap mass spectrometry. leilei zhang*†, yan wang†, dequan yu*, natural product research, 2015，29, 1350-1357.
7. design, synthesis and evaluation of novel derivatives of orotic acid amide as potent glucokinase activators, leilei zhang, shengquan hu, lei lei, yuliang zhang, lijing zhang, hongrui song, zhufang shen, zhiqiang feng*, letters in drug design & discovery, 2017， 14, 252- 261.
8. the stereoselective c-alkylation of chiral nitronic acid (4s*, 5r) -( )-4-(6-nitro-6-carbethoxymethyl)-5-[(1r)-menthyloxy]-3,4-dihydro-2(5h)-furanone, leilei zhang, zhiqiang feng*, j. indian chem. soc., 2014，91, 1335-1339.
9. (±)-f18对映异构体的hplc手性分离、绝对构型确定以及抗hiv-1活性研究，张蕾磊，薛海，李莉，陆小凡，陈志伟，刘刚*，药学学报，2015.

1、 超敏感荧光探针检验细菌中硝基还原酶及在细菌感染应用，cn201911008897.1.
2、 一种热激活延迟荧光探针分子、其制备及其在细胞成像中的应用, cn201910163693.9.