中国医学科学院酶与天然药物生物催化重点实验室-九游官网下载

科研队伍

朱平,男, 博士生导师。室主任、本所国重室副主任、中国菌物学会副理事长、《药学学报》和《菌物学报》编委等。在nature communications、green chemistry (封底图片)、molecular & cellular proteomics (封面图片)、acta pharmaceutica sinica b、fungal diversity等国际知名期刊发表多篇sci论文。累计授权8项中国专利和10项国际专利。参编著作6部。获得2011年中国药学会科学技术三等奖和“2020年度北京协和医学院优秀教师”称号。培养的博士研究生中分别有1名荣获“2018年度北京协和医学院优秀博士学位论文”和1名荣获“2019年度北京市普通高等学校优秀毕业生”称号。合作发现3ʹ-脱氧腺苷的降血脂功能及其作为ampk激动剂的作用机制,本所科技人员以此为先导物,已研制出新型降血脂药物;麦角生物碱的研究为相关企业提供了技术支撑。

微生物工程与天然药物合成生物学。目前主要开展:1) 药用天然产物生物合成基因的挖掘与酶的表征、生物合成途径解析及微生物系统中的途径重构研究; 2) 药用真菌、动植物内共生菌活性代谢产物的发现、生产与创新药物研究。

1. construction of acetyl-coa and dbat hybrid metabolic pathway for acetylation of 10- deacetylbaccatin iii to baccatin iii. hao wang, bo-yong zhang, ting gong, tian-jiao chen, jing-jing chen, jin-ling yang, ping zhu*. acta pharmaceutica sinica b, 2021, https://doi.org/10.1016/j.apsb.2021.03.029 (if=11.413)
2. de novo transcriptome sequencing of rhododendron molle and identification of genes involved in the biosynthesis of secondary metabolites. guo-lin zhou, ping zhu*. bmc plant biology, 2020, 20(1), 414. (if=4.215)
3. structures of β-glycosidase lxyl-p1-2 reveals the product binding state of gh3 family and a specific pocket for taxol recognition. lin yang#, tian-jiao chen#, fen wang li li, wen-bo yu, yi-kang si, jing-jing chen, wan-cang liu, ping zhu*, weimin gong *. communications biology, 2020, 3(1), 22. (if=6.268)
4. high-level soluble expression of human cu, zn superoxide dismutase with high activity in escherichia coli. jin-ling yang, xing-lun li, feng-lin jiang, ting gong, jing-jing chen, tian-jiao chen, ping zhu*. world journal of microbiology and biotechmology, 2020, 36, 106.(if=2.477)
5. construction and optimization of microbial cell factories for the sustainable production of bioactive dammarenediol-ii glucosides. zong-feng hu#, an-di gu#, lan liang, yan li, ting gong, jing-jing chen, tian-jiao chen, jin-ling yang*, ping zhu*. green chemistry, 2019, 219(12): 3286-3299. (back cover image of the present issue) (if=9.480)
6. fed-batch high-cell-density fermentation strategies for pichia pastoris growth and production. liu wc, inwood s, gong t, sharma a, yu ly*, ping zhu*. critical reviews in biotechnology, 2019, 39(2): 258-271. (if=8.108)
7. combinatorial mutation on the β-glycosidase specific to 7-β-xylosyltaxanes and increasing the mutated enzyme production by engineering the recombinant yeast. jing-jing chen, xiao liang, fen wang, yan-hua wen, tian-jiao chen, wan-cang liu, ting gong, jin-ling yang, ping zhu*. acta pharmaceutica sinica b, 2019, 9(3):626-638. (if=7.097)
8. advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites. yun-ming qiao, rui-lin yu, ping zhu*. rsc advances, 2019, 9, 35124–35134. (if=3.119)
9. epigenetic modification enhances ergot alkaloid production of claviceps purpurea. jing-jing chen, meng-yao han, ting gong, yun-ming qiao, jin-ling yang, ping zhu*. biotechnology letters, 2019, 41,1439–1449. (if=1.977)
10. site-directed mutagenesis of bata-glycoside hydrolase from lentinula edodes. jing-jing chen, xiao liang, tian-jiao chen, jin-ling yang and ping zhu*. molecules, 2019, 24, 59 (if=3.267)
11. tetrocarcin q, a new spirotetronate with a unique glycosyl group from a marine-derived actinomycete micromonospora carbonacea ls276. ting gong, xin zhen, xing-lun li, jing-jing chen, tian-jiao chen, jin-ling yang, ping zhu*. marine drugs, 2018, 16, 74. (if=4.379)
12. chrysoxanthones a–c, three new xanthone–chromanone heterdimers from sponge-associated penicillium chrysogenum hls111 treated with histone deacetylase inhibitor. xin zhen#, ting gong#, yan-hua wen, dao-jiang yan, jing-jing chen, ping zhu*. marine drugs, 2018, 16, 357. (if=4.379)
13. improving 10-deacetylbaccatin iii-10-β-oacetyltransferase catalytic fitness for taxol production. bing-juan li, hao wang, ting gong, jing-jing chen, tian-jiao chen, jin-ling yang, ping zhu*. nature communication, 2017, 8, 15544. (if=12.353)
14. cloning and characterization of the glycoside hydrolases that remove xylosyl group from 7-β-xylosyl-10-deacetyltaxol and its analogues. hai-li cheng, rui-yu zhao, tian-jiao chen, wen-bo yu, fen wang, ke-di cheng, ping zhu*. molecular & cellular proteomics, 2013, 12(8):2236-2248. (cover image and highlight from this issue) (if=7.254)
15. phylogenetic diversity of culturable fungi associated with two marine sponges: haliclona simulans and gelliodes carnosa, collected from the hainan island coastal waters of the south china sea. wen-chao liu, chang-qing li, ping zhu*. jin-ling yang, ke-di cheng. fungal diversity, 2010, 42:1-15. (if=5.074)

1. 2020. 北京协和医学院优秀教师奖. 朱平. 北京协和医学院. 2. 2011. 稀有天然药物生物合成与合成生物学研究. 程克棣,朱平,孔建强,王伟,涂珺,刘涛,袁玮,刘颖,张利平. 中国药学会科学技术奖. 三等奖.

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