王朝辉，研究员，博士生导师。2012年毕业于北京大学，获药剂学博士学位。2012年7月-2020年8月先后在美国普渡大学、德克萨斯大学西南医学中心从事科学研究工作。2020年10月作为“高层次引进人才”入职中国医学科院-北京协和医学院药物研究所，任研究员、课题组长。
主要从事生物大分子递送系统的研究和开发，迄今发表学术论文30余篇，包括以第一（含共同）作者和通讯作者发表于nature nanotechnology、angewandte chemie international edition、advanced materials、acs nano、biomaterial等著名期刊；其中1篇入选esi高被引论文，多篇论文被媒体和杂志作为研究亮点报道或入选top 25 hottest papers，在学界引起了广泛影响。应邀撰写英文专著章节1章。美国及pct专利申请6项，授权1项。积极推动研究成果的临床转化，开发的疫苗平台已转让onconano medicine, inc（onm-500），获得1540万美元的基金资助其临床研究，受邀担任技术顾问。参与开发的肿瘤实时成像探针（onm-100）已进入临床ii期，并获得美国fda的快速通道审评。
1. 智能药物输送系统的研究
2. 生物大分子递送系统的研究
3. 肿瘤联合免疫治疗
1. liang s, yao j, liu d, rao l*, chen x*, wang z*. harnessing nanomaterials for cancer sonodynamic immunotherapy. advanced materials. 2023, e2211130.
2. zhou m, liang s, liu d, ma k, peng y, wang z*. engineered nanoprobes for immune activation monitoring. acs nano. 2022, 16, 19940-19958.
3. luo m*, wang h*, wang z*, et al. a sting-activating nanovaccine for cancer immunotherapy. nature nanotechnology. 2017, 12, 648-654. (*co-first author, equal contribution).
4. wang z*, luo m*, mao c, et al. a redox-activatable fluorescent sensor for the high-throughput quantification of cytosolic delivery of macromolecules. angewandte chemie international edition. 2017, 129, 1339-1343.
5. aroh c*, wang z*, dobbs n, et al. innate immune activation by cgamp-pc7a nanoparticles leads to potent and long-acting antiretroviral response against hiv-1. journal of immunology. 2017, 199, 3840-3848. (*co-first author)
6. wang z, yu y, dai w, et al. a specific peptide ligand-modified lipid nanoparticle carrier for the inhibition of tumor metastasis growth. biomaterials. 2013, 34, 756-764.
7. wang z, yu y, ma j, et al. lyp-1 modification to enhance delivery of artemisinin or fluorescent probe loaded polymeric micelles to highly metastatic tumor and its lymphatics. molecular pharmaceutics. 2012, 9, 2646-2657.
8. wang z, yu y, dai w, lu j, cui j, wu h, yuan l, zhang h, wang x, wang j, zhang x, zhang q. the use of a tumor metastasis targeting peptide to deliver doxorubicin-containing liposomes to highly metastatic cancer. biomaterials. 2012, 33, 8451-8460.
9. wang z, wang z, sun c, et al. trimethylated chitosan-conjugated plga nanoparticles for the delivery of drugs to the brain. biomaterials. 2010, 31, 908-915.
1.stimuli-responsive and triggered drug delivery systems. wang z, zhang x, huang g, and gao j. edited by amiji m and singh a. the royal society of chemistry, pages 51-82. print isbn: 978-1-78801-113-6.
1. sting activating nanovaccine for immunotherapy. 美国及pct专利. (utsd.p3022us.p1、pct/us2017/020451). 申请日：2016-03-02
1.2010．辽宁省自然科学奖论文类一等奖. 王思玲、王占友、孙长山、王朝辉. 辽宁省
