林明宝，男，副研究员，硕士生导师。现就职于中国医学科学院药物研究所，从事炎症与免疫药理学及其创新药物研究。主持国家自然科学基金面上、北京市自然科学基金面上、协和青年基金以及国家重点实验室项目等多项；负责完成中药六类、八类等新药品种12个；在研临床前新药开发项目3项。以第一或通迅作者发表论文20余篇，其中sci论文15篇；申请发明专利18项，授权3项。
教育背景
2009/09-2013/03，浙江大学，药理学，博士
2005/09-2008/06，江西中医药大学，中药学，硕士
1997/09-2002/06，江西医学院，预防医学，本科
工作经历
2013/08-至今，中国医学科学院，药物研究所，助理研究员、副研究员
2007/04-2009/09，江西省中西医结合医院，副研究员、检验科主任
2002/07-2007/03，江西省中医药研究院，中药所/细胞生物所，实研、助研
1. 炎症与免疫药理学及其创新药物发现
2. 呼吸疾病（哮喘、copd等）炎症免疫调控机制与新靶点发现及其创新药研究
3. 免疫介导的再生障碍性贫血病理机制及其靶点与新药发现研究
4. 多成分多靶点组分中药的开发及其在慢性复杂性疾病中的作用机制研究
1. pei ma#, shuyi li#, hui yang, jiqiao yuan, ziqian zhang, xuyu li, nan fang, mingbao lin* and qi hou*. comparative rna‐seq transcriptome analysis on pulmonary inflammation in a mouse model of asthma-copd overlap syndrome. frontiers in cell and developmental biology. 2021，doi: 10.3389/fcell.2021.628957.
2. shuyi li, hui yang, jiqiao yuan, ziqian zhang, xuyu li, nan fang, mingbao lin*, qi hou*. syk-targeted, a new 3-arylbenzofuran derivative eapp-2 blocks airway inflammation of asthma–copd overlap in vivo and in vitro. journal of inflammation research. 2021，14：2173-2185.
3. yasi ding#, weibin tang#, fei pei#, lixia fu, pei ma, jinye bai, mingbao lin*, yunbao liu*, qi hou*. brusatol derivative - 34 attenuates allergic airway inflammation via inhibition of the syk pathway. frontiers in pharmacology. 2021, doi: 10.3389/fphar.2021.587417.
4. hui yang# ,wei sun#,yan-nan fan, shu-yi li, ji-qiao yuan, zi-qian zhang, xu-yu li, ming-bao lin* , and qi hou*. perilla leaf extract attenuates asthma airway inflammation by blocking the syk pathway. mediators of inflammation. 2021，2021：6611219.
5. hui yang,wei sun, pei ma,chunsuo yao,yannan fan,shuyi li,jiqiao yuan,xuyu li, mingbao lin*,qi hou*. multiple components rapidly screened from perilla leaves attenuate asthma airway inflammation by synergistic targeting on syk. journal of inflammation research. 2020:13 897–911.
6. pei ma, lifeng yue, hui yang, yannan fan, jinye bai, shuyi li, jiqiao yuan, ziqian zhang, chunsuo yao, mingbao lin*, qi hou*. hondroprotective and anti-inflammatory effects of amurensin h by regulating tlr4/syk/nf-κb signals. j cell mol med. 2020;24:1958–1968
7. yannan fan, ziqian zhang, chunsuo yao, jinye bai, hui yang, pei ma, yiyao fan, shuyi li, jiqiao yuan, mingbao lin* and qi hou*. amurensin h, a derivative from resveratrol, ameliorates lipopolysaccharide / cigarette smoke‐induced airway inflammation by blocking the syk/nf-κb pathway. frontiers in pharmacology. 2019, 10: 1157.
8. hui yang#, jing guan#, pei ma, yannan fan, jinye bai, shuyi li, jiqiao yuan,yecheng jin, mingbao lin#*, jianmin zhang*, and qi hou*. beneficial effects of qingzixiaoban granule on henoch–sch¨onlein purpura nephritis mice through inhibiting immune complex deposition and th2 immunodeviation. ecam. 2019: 3050248.
9. lixia fu#, jing guan#, yujia zhang#, pei ma#, yuanyuan zhuang, jinye bai, yasi ding, qi hou, wan gong, mingbao lin*, wensheng zheng*, jianmin zhang*. tulobuterol patch alleviates allergic asthmic inflammation by blockade of syk and nf-κb activation in mice. oncotarget. 2018, 9(15): 12154-12163.
10. yuanyuan zhuang#, jiabao liu#, pei ma#, jinye bai, yasi ding, hui yang, yannan fan, mingbao lin*, shuai li* & qi hou*. tamarixinin a alleviates joint destruction of rheumatoid arthritis by blockade of mapk and nf-κb activation. frontiers in pharmacology. 2017, 8: 538.doi:10.3389/fphar.2017.00538.
11. jin-qian yu#, ming-bao lin#, an-jun deng**, qi hou, zhi-hui zhang, shao-peng yuan, ren-tao jiang, hai-lin qin*. phytochemistry. 2017, 138 (2017):152-162.
12. pei ma#, ya-si ding#, ling-ling xuan#, lin wang, ji shi, jin-ye bai, ming-bao lin*, wen-sheng zheng* & qi hou*. anti-inflammatory effect of a resveratrol derivative 3,4,5-trimethoxy-4′,5′-dihydroxytrans-stilbene (wl-09-5) via ros-mediated nf-κb pathway. journal of asian natural products research. 2016, 18(10): 1004-1013.
