陈晶晶，博士，副研究员。2014年毕业于南京师范大学，微生物学专业，获理学博士学位。同年进入中国医学科学院药物研究所生物合成室工作，主要从事活性天然产物的生物合成与合成生物学研究。作为项目负责人，主持国家自然科学基金青年项目1项，中央级公益性科研院所基本科研业务费1项；作为骨干人员，参与国家自然科学基金面上项目、中国医学科学院医学与健康科技创新工程、国家“十三五”重大新药创制专项等。发表sci论文20余篇，其中以第一作者身份发表sci论文9篇；申请专利5项，授权2项；参与编写专著1部。
活性天然产物的生物合成与合成生物学研究
1. 通过基因挖掘和功能表征，解析活性天然产物的未知生物合成途径；
2. 利用蛋白质工程改善酶特性，提高其稳定性或催化效率，应用于天然药物高效酶法合成；
3. 运用合成生物学技术，在微生物底盘细胞中设计和构建活性天然产物的生物合成途径，高效生产活性天然产物，拓展药物来源。
1. jing-jing chen, xiao liang, tian-jiao chen, jin-ling yang and ping zhu*. mutation of key residues in β-glycosidase lxyl-p1-2 for improved activity. catalysts, 2021, 11, 1042.
2. jing-jing chen, xiao liang, fen wang, yan-hua wen, tian-jiao chen,wan-cang liu, ting gong, jin-ling yang, ping zhu*. combinatorial mutation on the β-glycosidase specificto7-β-xylosyltaxanes and increasing the mutated enzyme production by engineering the recombinant yeast. acta pharmaceutica sinica b, 2019, 9(3): 626–638.
3. jing-jing chen, meng-yao han, ting gong, yun-ming qiao, jin-ling yang, ping zhu*. epigenetic modification enhances ergot alkaloid production of claviceps purpurea. biotechnology letters, 2019, 41: 1439–1449.
4. jing-jing chen, xiao liang, tian-jiao chen, jin-ling yang and ping zhu*. site-directed mutagenesis of a β-glycoside hydrolase from lentinula edodes. molecules, 2019, 24, 59.
5. jing-jing chen, xiao liang, hui-xian li, tian-jiao chen, ping zhu*. improving the catalytic property of the glycoside hydrolase lxyl-p1–2 by directed evolution. molecules, 2017, 22(12): 2133.
6. jing-jing chen, meng-yao han, ting gong, jin-ling yang and ping zhu*. recent progress in ergot alkaloid research. rsc advances, 2017, 7, 27384.
7. jing-jing chen, yang-yang yong, xian xia, ze-liang wang, you-xing liang, zhao zhang and ling lu*, the excreted polysaccharide of pleurotus eryngii inhibits the foam-cell formation via down-regulation of cd36. carbohydrate polymers, 2014, 112: 16-23.
8. jing-jing chen #, yang-yang yong #, meichun xing, yifan gu, zhao zhang, shizhu zhang and ling lu*. characterization of polysaccharides with marked inhibitory effect on lipid accumulation in pleurotus eryngii. carbohydrate polymers, 2013, 97: 604-613
9. jing-jing chen, dong mao, yang-yang yong, jieli li, hua wei and ling lu*, hepatoprotective and hypolipidemic effects of water-soluble polysaccharidic extract of pleurotus eryngii. food chemistry, 2012, 130: 687-694.
10. chen zhou, tianjiao chen, andi gu, zongfeng hu, yan li, ting gong, jingjing chen, jinling yang*, ping zhu*. combining protein and metabolic engineering to achieve green biosynthesis of 12β-o-glc-ppd in saccharomyces cerevisiae. green chemistry, 2023, 25(4): 1356-1367.
11. fenglin jiang, chen zhou, yan li, haidong deng, ting gong, jingjing chen, tianjiao chen, jinling yang*, ping zhu*. metabolic engineering of yeasts for green and sustainable production of bioactive ginsenosides f2 and 3β,20s-di-o-glc-dm. acta pharmaceutica sinica b, 2022, 12(7): 3167-3176.
12. yanhua wen, tianjiao chen, longyu jiang, li li, mengbo guo, yu peng, jingjing chen, fei pei, jinling yang, ruishan wang, ting gong*, ping zhu*. unusual (2r,6r)-bicyclo[3.1.1]heptane ring construction in fungal a-trans-bergamotene biosynthesis. iscience, 2022, 25: 104030.
13. guolin zhou, yong li, fei pei, ting gong, tianjiao chen, jingjing chen, jinling yang, qihan li*, shishan yu*, ping zhu*. chromosome-scale genome assembly of rhododendron molle provides insights into its evolution and terpenoid biosynthesis. bmc plant biology, 2022, 22: 342.
14. lin yang#, tian-jiao chen#, fen wang, li li, wen-bo yu, yi-kang si, jing-jing chen, wan-cang liu, ping zhu*, weimin gong*. structures of β-glycosidase lxyl-p1-2 reveals the product binding state of gh3 family and a specific pocket for taxol recognition. communications biology, 2020, 3(1): 22
15. zong-feng hu, an-di gu, lan liang, yan li, ting gong, jing-jing chen, tian-jiao chen, jin-ling yang* and ping zhu*. construction and optimization of microbial cell factories for sustainable production of bioactive dammarenediol-ii glucosides. green chemistry, 2019, 21(12): 3286-3299
16. huichao liang, zongfeng hu, tingting zhang, ting gong, jingjing chen, ping zhu, yan li, jinling yang*. production of a bioactive unnatural ginsenoside by metabolically engineered yeasts based on a new udp-glycosyltransferase from bacillus subtilis. metabolic engineering, 2017, 44: 60-69
17. bing-juan li, hao wang, ting gong, jing-jing chen, tian-jiao chen, jin-ling yang, ping zhu*. improving 10-deacetylbaccatin iii-10-β-o-acetyltransferase catalytic fitness for taxol production. nature communications, 2017, 8:15544
18. wancang liu, ting gong, qinghua wang, xiao liang, jingjing chen, ping zhu*, scaling-up fermentation of pichia pastoris to demonstration-scale using new methanol-feeding strategy and increased air pressure instead of pure oxygen supplement. scientific reports, 2016, 6:18439
1. 《中国食用药用菌化学》. 陈若芸 主编, 上海科学技术文献出版社, 2016 (第十六章 麦角菌).
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2. 杨金玲，朱平，梁会超，胡宗风，梁兰，张婷婷，巩婷，陈晶晶。枯草芽孢杆菌糖基转移酶及其应用。专利号：zl 201810303159.9
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4. 朱平，张波泳，王豪，巩婷，陈天娇，陈晶晶，杨金玲。酰基/芳酰基a的酶法制备技术。 申请号：202110452209.1
5. 杨金玲，朱平，胡宗风，顾安頔，姜逢霖，巩婷，陈晶晶。生产稀有人参皂苷20s-o-glc-dm的重组菌及其应用。申请号：201910063187.2
