教育背景
1987/09-1991/07，成都科技大学(现四川大学)，应用化学系，分析化学专业，学士
1995/09-1998/07，山西大学，化学系，分析化学专业，硕士
2001/09-2004/07，中国协和医科大学，药物分析专业，博士
工作经历
1991/07-1995/09，山西医学院，卫生系，助教
1998/07-2001/08，山西医科大学，药学系，讲师
2004/08-至今，中国医学科学院&北京协和医学院药物研究所，国家药物及代谢产物分析研究中心，历任助理研究员、副研究员、研究员
代谢紊乱是疾病的主要原因，为新药研发提供了潜在靶点和重要依据。我们开发先进的质谱成像技术及多功能液相色谱-质谱联用方法，旨在获取生物体代谢网络及其调控规律的新认识，同时致力代谢发现的转化应用。目前的研究工作分为以下方面：
1. 代谢组学技术开发，包括细胞代谢组学、空间成像代谢流、原位衍生化质谱成像
2. 功能代谢物的发现与验证
3. 药物早期药效毒性评价
4. 激素依赖性疾病的代谢基础
qingce zang†, chenglong sun†, xiaoping chu, limei li, wenqiang gan, zitong zhao, yongmei song, jiuming he, ruiping zhang*, zeper abliz*. spatially resolved metabolomics combined with multicellular tumor spheroids to discover cancer tissue relevant metabolic signatures. anal chim acta, 2021, 10.1016/j.aca.2021.338342
2. xiaoyu xu†, liping wang†, qingce zang, shanshan li, limei li, zhixing wang, jiuming he, boqin qiang, wei han, ruiping zhang, xiaozhong peng* and zeper abliz*. rewiring of purine metabolism in response to acidosis stress in glioma stem cells. cell death and disease, 2021, 12:277
3. zhonghua wang, xiaoyu xu, bingshu he, jinghua guo, baoxin zhao, yanping zhang, zhi zhou, xia zhou, ruiping zhang*, zeper abliz*. the impact of chronic environmental metal and benzene exposure on human urinary metabolome among chinese children and the elderly population. ecotoxicology and environmental safety, 2019, 169: 232-239.
4. xiaoyu xu, qingce zang, rui zhang, jiaxing liu, jiuming he, ruiping zhang*, zeper abliz. systematic optimization and evaluation of sample pretreatment methods for lc-ms-based metabolomics analysis of adherent mammalian cancer cells. anal methods, 2019, 11: 3014-3022.
5. xiao-chao zhang†, qingce zang†, hansen zhao, xiaoxiao ma, xingyu pan, jiaxin feng, sichun zhang, ruiping zhang, zeper abliz*, xinrong zhang*. combination of droplet extraction and pico-esi-ms allows the identification of metabolites from single cancer cells. anal chem, 2018, 90(16): 9897-9903.
6. rui zhang, peishan hu, qingce zang, xiaofei yue, zhi zhou, xiaoyu xu, jing xu, shanshan li, yanhua chen, boqin qiang, xiaozhong peng, wei han,* ruiping zhang * and zeper abliz. lc-ms-based metabolomics reveals metabolic signatures related to glioma stem-like cell selfrenewal and differentiation. rsc advances, 2017, 7: 24221–24232.
7. zhonghua wang, yajie zheng, baoxin zhao, yanping zhang, zhe liu, jing xu, yanhua chen, zhao yang, fenfen wang, huiqing wang, jiuming he, ruiping zhang,* and zeper abliz*. human metabolic responses to chronic environmental polycyclic aromatic hydrocarbon exposure by a metabolomic approach. journal of proteome research, 2015, 14: 2583–2593.
8. zhonghua wang, baoxin zhao, xuhui liu, yajie zheng, junxia wang, ruiping zhang* and zeper abliz. a rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of s-phenylmercapturic acid in human urine. anal methods, 2013, 5: 6081–6085.
9. jiang huang, jianghao sun, yanhua chen, yongmei song, lijia dong, qinmin zhan, ruiping zhang*, zeper abliz*. analysis of multiplex endogenous estrogen metabolites in human urine using ultra-fast liquid chromatography-tandem mass spectrometry: a case study for breast cancer. anal chim acta, 2012, 711: 60–68.
10. yaping tian, jiuming he, ruiping zhang*, haining lv, shuanggang ma, yanhua chen, shishan yu, xiaoguang chen, yan wu, wenyi he, zeper abliz*. integrated rapid resolution liquid chromatography-tandem mass spectrometric approach for screening and identification of metabolites of the potential anticancer agent 3,6,7-trimethoxyphenanthroindolizidine in rat urine. anal chim acta, 2012, 731: 60–67.
