王亚男，男，博士，副研究员，硕士研究生导师，现为中国医学科学院药物研究所分析室党支部书记。2012年7月毕业于北京协和医学院，获药物化学专业博士学位。2012年8月在中国医学科学院药物研究所药物分析研究室核磁组工作至今，先后任助理研究员、副研究员。主要从事核磁共振分析新技术新方法在新药研发中的应用与创新，建立了领先的以活性结构为导向的基于液相-核磁共振联用技术高效快速发现天然产物活性物质的应用分析策略。目前承担北京协和医学院《波谱解析（硕士）》、《药物分析》、《药物化学实验》研究生课程授课，其中《波谱解析》在2018年被评为全国医药学研究生精品建设课程，《药物分析》荣获2022年北京协和医学院研究生精品课程。已发表国内外论文70余篇，sci论文40余篇，获得授权专利3项，申请专利3项，软件著作权1项。参与编写科研工具书《分析化学手册. 7a. 氢-1核磁共振波谱分析（第三版）》及《药物分析技术进展与应用》专业书籍。1项教学案例入选全国药学专业学位研究生教育指导委员会2021年第五届全国药学专业学位优秀教学案例。
1.核磁共振代谢组学分析技术在药物研发中的应用研究
2.核磁共振分析新技术新方法及其在药物研发中的应用研究
3.基于液相-核磁共振联用技术的活性物质快速发现研究
1. xinjian li, zhe wang, bowen zheng, yanan wang,* and jinlan zhang*, novel strategy to rapidly profile and identify oxidized species of polysorbate 80 using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry. analytical chemistry, 2023. (accepted)
2. tian, m.#; wang, y.-n.#; lu, a.; zhang, q.; li, x.; zhang, n.; zhang, j.; wang, s., from metabolomic analysis to quality assessment and biosynthetic insight in traditional chinese medicine: mulberry tree as a case study. phytochemical analysis, 2022.
3. nmr-based metabolomic approach to understanding zeng-sheng-ping-induced hepatotoxicity, and identifying possible toxic constituents by lc-ms profiles. wu, y.; wang, j.-q.; wang, y.-n.; pang, x.-x.; bao, j.; guan, x.-b.; wang, s.-j., journal of pharmaceutical and biomedical analysis, 2022.
4. zhang, d. y.; zhou, j. j.; yang, h.; wang, m.; wang, y. n.; liu, s.; zhang, z. m.; zhuang, p. y.; wang, x. x.; liu, h., chlorahupetenes a-d, four eudesmane-type sesquiterpenoid dimer enantiomers with two unusual carbon skeletons from chloranthus henryi var. hupehensis. journal of organic chemistry 2022.
5. wang, l.; xia, g.; xia, h.; wei, x.; wang, y.; lin, s., ( )/(−)-yanhusamides a−c, three pairs of unprecedented benzylisoquinoline-pyrrole hetero-dimeric alkaloid enantiomers from corydalis yanhusuo. acta pharmaceutica sinica b, 2022.
6. pei, y.-h.; zhang, l.-h.; wu, x.-l.; wu, h.-h.; wang, h.-f.; wang, y.-n.; chen, g., polyhydroxylated bergamotane-type sesquiterpenoids from cultures of paraconiothyrium sporulosum yk-03 and their absolute configurations. phytochemistry, 2022.
7. xenoacremones d–h, bioactive tyrosine-decahydrofluorene analogues from the plant-derived fungus xenoacremonium sinensis. liu, z.; liu, l.; wang, a.; li, l.; zhao, s.; wang, y.-n.; sun, y., marine drugs, 2022.
8. nine sesquiterpenoid dimers with four unprecedented types of carbon skeleton from chloranthus henryi var. hupehensis. zhang, d.-y.; wang, x.-x.; wang, y.-n.; wang, m.; zhuang, p.-y.; jin, y.; liu, h., organic chemistry frontiers, 2021.
9. xanthanoltrimer a–c: three xanthanolide sesquiterpene trimers from the fruits of xanthium italicum moretti isolated by hplc-ms-spe-nmr. fu, j.; wang, y.-n.; ma, s.-g.; li, l.; wang, x.-j.; li, y.; liu, y.-b.; qu, j.; yu, s.-s., organic chemistry frontiers, 2021.
10. a fast strategy for profiling and identifying pharmaceutic excipient polysorbates by ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry. wang, z.#; wang, y.-n.#; tie, c.; zhang, j.-l., j chromatogr a, 2020.
11. insight into medicinal chemistry behind traditional chinese medicines: p-hydroxybenzyl alcohol-derived dimers and trimers from gastrodia elata. wang, y.; zhang, m.; zhou, x.; xu, c.; zhu, c.; yuan, y.; chen, n.; yang, y.; guo, q.; shi, j., natural products and bioprospecting, 2020.
12. trichodestruxins a–d: cytotoxic cyclodepsipeptides from the endophytic fungus trichoderma harzianum. liu, z.; sun, y. *; tang, m.; sun, p.; wang, a.; hao, y.; wang, y.*; pei, y.*,journal of natural products, 2020.
13. enzymatic intermolecular hetero-diels-alder reaction in the biosynthesis of tropolonic sesquiterpenes. chen, q.; gao, j.; jamieson, c.; liu, j.; ohashi, m.; bai, j.; yan, d.; liu, b.; che, y.; wang, y.; houk, k. n.; hu, y., j am chem soc, 2019.
14. crystal structure of dimethyl 3,12-dibenzyl-6,10-diphenyl-3,12-diazapentacyclo [6.3.1.02.7.04.11.05.9]-dodecane-7,11-dicarboxylate — acetone (2/1), c40h38n2o2 ？ 0.5c3h6o. wang, y.-n.; wu, y.; tian, y., zeitschrift für kristallographie - new crystal structures, 2019.
15. new glycosides from the twigs and leaves of rhododendron latoucheae. wang, y.-n.#; liu, f.#; li, y.; ma, s.-g.; qu, j.; liu, y.-b.; niu, c.-s.; tang, z.-h.; li, y.-h.; wang, r.-b., journal of asian natural products research, 2019.
16. triterpenoids from the twigs and leaves of rhododendron latoucheae by hplc？ms？spe？nmr. liu, f.#; wang, y.-n.#; li, y.; ma, s.-g.; qu, j.; liu, y.-b.; niu, c.-s.; tang, z.-h.; li, y.-h.; li, l., tetrahedron, 2019.
17. purpurolide a, 5/5/5 spirocyclic sesquiterpene lactone in nature from the endophytic fungus penicillium purpurogenum. wang, y.-n.#; xia, g.-y.#; wang, l.-y.; ge, g.-b.; zhang, h.-w.; zhang, j.-f.; wu, y.-z.; lin, s., organic letters, 2018.
18. diphenyl ethers from a marine-derived aspergillus sydowii. wang, y.-n.#; mou, y.-h.#; dong, y.#; wu, y.; liu, b.-y.; bai, j.; yan, d.-j.; zhang, l.; feng, d.-q.; pei, y.-h., mar. drugs, 2018.
1. 《药物分析技术进展与应用》，编者，中国协和医科大学出版社，2021.
2. 《分析化学手册. 7a. 氢-1核磁共振波谱分析（第三版）》，编者，化学工业出版社，2016.
